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dc.contributor.authorFrew, Emmaen
dc.contributor.authorGoranitis, Iliasen
dc.contributor.authorCoast, Joannaen
dc.contributor.authorDay, Eden
dc.contributor.authorCopello, Alexen
dc.contributor.authorFreemantle, Nicken
dc.contributor.authorSeddon, Jennifer L.en
dc.contributor.authorBennett, Carmelen
dc.date.accessioned2019-03-27T10:54:04Z
dc.date.available2019-03-27T10:54:04Z
dc.date.issued2019-03-26
dc.identifier.citationFrew E., Goranitis I., Coast J., Day E., Copello A., Freemantle N., Seddon J., Bennett C. (2016) 'Measuring health and broader well-being benefits in the context of opiate dependence: the psychometric performance of the ICECAP-A and the EQ-5D-5L', Value in Health, 19 (6), pp.820-828.en
dc.identifier.issn1098-3015
dc.identifier.pmid27712710
dc.identifier.doi10.1016/j.jval.2016.04.010
dc.identifier.urihttp://hdl.handle.net/10547/623220
dc.description.abstractBackground Measuring outcomes in economic evaluations of social care interventions is challenging because both health and well-being benefits are evident. The ICEpop CAPability instrument for adults (ICECAP-A) and the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) are measures potentially suitable for the economic evaluation of treatments for substance use disorders. Evidence for their validity in this context is, however, lacking. Objectives To assess the construct validity of the ICECAP-A and the EQ-5D-5L in terms of convergent and discriminative validity and sensitivity to change on the basis of standard clinical measures (Clinical Outcomes in Routine Evaluation-Outcome Measure, Treatment Outcomes Profile, Interpersonal Support Evaluation List, Leeds Dependence Questionnaire, and Social Satisfaction Questionnaire). Methods A secondary analysis of pilot trial data for heroin users in opiate substitution treatment was conducted. Baseline convergence with clinical measures was assessed using the Pearson correlation coefficient. Discriminative validity was assessed using one-way analysis of variance and stepwise regressions. Sensitivity to changes in clinical indicators was assessed at 3 and 12 months using the standardized response mean statistic and parametric and nonparametric testing. Results Both measures had the same level of construct validity, except for clinical indicators of well-being, for which the ICECAP-A performed better. The ICECAP-A was sensitive to changes in both health and well-being indicators. The EQ-5D-5L had lower levels of sensitivity to change, and a ceiling effect (27%), particularly evident in the dimensions of self-care (89%), mobility (75%), and usual activities (72%). Conclusions The findings support the construct validity of both measures, but the ICECAP-A gives more attention to broader impacts and is more sensitive to change. The ICECAP-A shows promise in evaluating treatments for substance use disorders for which recovery is the desired outcome.
dc.language.isoenen
dc.publisherElsevier Ltden
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S1098301516304351en
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectconstruct validityen
dc.subjectICECAPen
dc.subjectEQ-5Den
dc.subjectsensitivity to changeen
dc.subjectaddictionen
dc.subjecteconomic evaluationen
dc.subjectmental healthen
dc.subjectoutcome valuationen
dc.subjectL900 Others in Social studiesen
dc.titleMeasuring health and broader well-being benefits in the context of opiate dependence: the psychometric performance of the ICECAP-A and the EQ-5D-5Len
dc.typeArticleen
dc.contributor.departmentUniversity of Birminghamen
dc.contributor.departmentUniversity of Bristolen
dc.contributor.departmentBirmingham and Solihull Mental Health NHS Foundation Trusten
dc.contributor.departmentKing’s College Londonen
dc.contributor.departmentUniversity College Londonen
dc.identifier.journalValue in Healthen
dc.date.updated2019-03-27T10:50:22Z
dc.description.noteauthor's version sourced from http://discovery.ucl.ac.uk/1524729/
refterms.dateFOA2020-04-23T08:40:59Z
html.description.abstractBackground Measuring outcomes in economic evaluations of social care interventions is challenging because both health and well-being benefits are evident. The ICEpop CAPability instrument for adults (ICECAP-A) and the five-level EuroQol five-dimensional questionnaire (EQ-5D-5L) are measures potentially suitable for the economic evaluation of treatments for substance use disorders. Evidence for their validity in this context is, however, lacking. Objectives To assess the construct validity of the ICECAP-A and the EQ-5D-5L in terms of convergent and discriminative validity and sensitivity to change on the basis of standard clinical measures (Clinical Outcomes in Routine Evaluation-Outcome Measure, Treatment Outcomes Profile, Interpersonal Support Evaluation List, Leeds Dependence Questionnaire, and Social Satisfaction Questionnaire). Methods A secondary analysis of pilot trial data for heroin users in opiate substitution treatment was conducted. Baseline convergence with clinical measures was assessed using the Pearson correlation coefficient. Discriminative validity was assessed using one-way analysis of variance and stepwise regressions. Sensitivity to changes in clinical indicators was assessed at 3 and 12 months using the standardized response mean statistic and parametric and nonparametric testing. Results Both measures had the same level of construct validity, except for clinical indicators of well-being, for which the ICECAP-A performed better. The ICECAP-A was sensitive to changes in both health and well-being indicators. The EQ-5D-5L had lower levels of sensitivity to change, and a ceiling effect (27%), particularly evident in the dimensions of self-care (89%), mobility (75%), and usual activities (72%). Conclusions The findings support the construct validity of both measures, but the ICECAP-A gives more attention to broader impacts and is more sensitive to change. The ICECAP-A shows promise in evaluating treatments for substance use disorders for which recovery is the desired outcome.


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