IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
AuthorsYánez, Diana C.
Lange, Ulrike C.
Adams, David J.
Furmanski, Anna L.
MetadataShow full item record
AbstractT cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.
CitationYánez DC, Sahni H, Ross S, Solanki A, Lau CI, Papaioannou E, Barbarulo A, Powell R, Lange UC, Adams DJ, Barenco M, Ono M, D'Acquisto F, Furmanski AL, Crompton T (2019) 'IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation', European Journal of Immunology, 49 (1), pp.66-78.
JournalEuropean Journal of Immunology
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