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    A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles

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    Authors
    Zariwala, Mohammed Gulrez
    Elsaid, Naba
    Jackson, Timothy L.
    Corral López, Francisco
    Farnaud, Sébastien
    Somavarapu, Satyanarayana
    Renshaw, Derek
    Affiliation
    University of Westminster
    University College London
    King's College Hospital
    University of Bedfordshire
    Issue Date
    2013-11-18
    Subjects
    iron
    
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    Abstract
    Iron (Fe) loaded solid lipid nanoparticles (SLN's) were formulated using stearic acid and iron absorption was evaluated in vitro using the cell line Caco-2 with intracellular ferritin formation as a marker of iron absorption. Iron loading was optimised at 1% Fe (w/w) lipid since an inverse relation was observed between initial iron concentration and SLN iron incorporation efficiency. Chitosan (Chi) was included to prepare chitosan coated SLN's. Particle size analysis revealed a sub-micron size range (300.3±31.75 nm to 495.1±80.42 nm), with chitosan containing particles having the largest dimensions. As expected, chitosan (0.1%, 0.2% and 0.4% w/v) conferred a net positive charge on the particle surface in a concentration dependent manner. For iron absorption experiments equal doses of Fe (20 μM) from selected formulations (SLN-FeA and SLN-Fe-ChiB) were added to Caco-2 cells and intracellular ferritin protein concentrations determined. Caco-2 iron absorption from SLN-FeA (583.98±40.83 ng/mg cell protein) and chitosan containing SLN-Fe-ChiB (642.77±29.37 ng/mg cell protein) were 13.42% and 24.9% greater than that from ferrous sulphate (FeSO4) reference (514.66±20.43 ng/mg cell protein) (p≤0.05). We demonstrate for the first time preparation, characterisation and superior iron absorption in vitro from SLN's, suggesting the potential of these formulations as a novel system for oral iron delivery.
    Citation
    Zariwala MG, Elsaid N, Jackson TL, Corral López F, Farnaud S, Somavarapu S, Renshaw D (2013) 'A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles', International Journal of Pharmaceutics, 456 (2), pp.400-7.
    Publisher
    Elsevier
    Journal
    International Journal of Pharmaceutics
    URI
    http://hdl.handle.net/10547/623165
    DOI
    10.1016/j.ijpharm.2013.08.070
    PubMed ID
    24012860
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S037851731300803X
    Type
    Article
    Language
    en
    ISSN
    0378-5173
    EISSN
    0378-5173
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ijpharm.2013.08.070
    Scopus Count
    Collections
    Biomedical and biological science

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