Show simple item record

dc.contributor.authorDodsworth, Stevenen
dc.date.accessioned2019-02-12T10:37:12Z
dc.date.available2019-02-12T10:37:12Z
dc.date.issued2009-09-25
dc.identifier.citationDodsworth S. (2009) 'A diverse and intricate signalling network regulates stem cell fate in the shoot apical meristem', Developmental Biology, 336 (1), pp.1-9.en
dc.identifier.issn0012-1606
dc.identifier.pmid19782675
dc.identifier.doi10.1016/j.ydbio.2009.09.031
dc.identifier.urihttp://hdl.handle.net/10547/623151
dc.description.abstractAt the shoot apex of plants is a small region known as the shoot apical meristem (SAM) that maintains a population of undifferentiated (stem) cells whilst providing cells for developing lateral organs and the stem. All aerial structures of the plant develop from the SAM post-embryogenesis, enabling plants to grow in a characteristic modular fashion with great phenotypic and developmental plasticity throughout their lifetime. The maintenance of the stem cell population is intimately balanced with cell recruitment into differentiating tissues through intercellular communication involving a complex signalling network. Recent studies have shown that diverse regulators function in SAM maintenance, many of which converge on the WUSCHEL (WUS) gene. In this review the diverse regulatory modules that function in SAM maintenance are discussed: transcriptional and epigenetic control, hormonal regulation, and the balance with organogenesis. The central role of WUS as an integrator of multiple signals is highlighted; in addition, accessory feedback loops emerge as a feature enabling dynamic regulation of the stem cell niche.
dc.language.isoenen
dc.publisherAcademic Press Inc.en
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0012160609012160en
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.subjectcytokininen
dc.subjectmeristemen
dc.subjectstem cellen
dc.subjectWUSCHELen
dc.subjectCLAVATAen
dc.subjectKNOXen
dc.subjectchromatin remodellingen
dc.subjectgibberellinen
dc.subjectC400 Geneticsen
dc.titleA diverse and intricate signalling network regulates stem cell fate in the shoot apical meristemen
dc.typeArticleen
dc.contributor.departmentUniversity of Cambridgeen
dc.identifier.journalDevelopmental Biologyen
dc.date.updated2019-02-11T12:05:02Z
dc.description.notecannot make pdf available - but is before April 2016. Passing metadata only
html.description.abstractAt the shoot apex of plants is a small region known as the shoot apical meristem (SAM) that maintains a population of undifferentiated (stem) cells whilst providing cells for developing lateral organs and the stem. All aerial structures of the plant develop from the SAM post-embryogenesis, enabling plants to grow in a characteristic modular fashion with great phenotypic and developmental plasticity throughout their lifetime. The maintenance of the stem cell population is intimately balanced with cell recruitment into differentiating tissues through intercellular communication involving a complex signalling network. Recent studies have shown that diverse regulators function in SAM maintenance, many of which converge on the WUSCHEL (WUS) gene. In this review the diverse regulatory modules that function in SAM maintenance are discussed: transcriptional and epigenetic control, hormonal regulation, and the balance with organogenesis. The central role of WUS as an integrator of multiple signals is highlighted; in addition, accessory feedback loops emerge as a feature enabling dynamic regulation of the stem cell niche.


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record