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    A diverse and intricate signalling network regulates stem cell fate in the shoot apical meristem

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    Authors
    Dodsworth, Steven
    Affiliation
    University of Cambridge
    Issue Date
    2009-09-25
    Subjects
    cytokinin
    meristem
    stem cell
    WUSCHEL
    CLAVATA
    KNOX
    chromatin remodelling
    gibberellin
    C400 Genetics
    
    Metadata
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    Abstract
    At the shoot apex of plants is a small region known as the shoot apical meristem (SAM) that maintains a population of undifferentiated (stem) cells whilst providing cells for developing lateral organs and the stem. All aerial structures of the plant develop from the SAM post-embryogenesis, enabling plants to grow in a characteristic modular fashion with great phenotypic and developmental plasticity throughout their lifetime. The maintenance of the stem cell population is intimately balanced with cell recruitment into differentiating tissues through intercellular communication involving a complex signalling network. Recent studies have shown that diverse regulators function in SAM maintenance, many of which converge on the WUSCHEL (WUS) gene. In this review the diverse regulatory modules that function in SAM maintenance are discussed: transcriptional and epigenetic control, hormonal regulation, and the balance with organogenesis. The central role of WUS as an integrator of multiple signals is highlighted; in addition, accessory feedback loops emerge as a feature enabling dynamic regulation of the stem cell niche.
    Citation
    Dodsworth S. (2009) 'A diverse and intricate signalling network regulates stem cell fate in the shoot apical meristem', Developmental Biology, 336 (1), pp.1-9.
    Publisher
    Academic Press Inc.
    Journal
    Developmental Biology
    URI
    http://hdl.handle.net/10547/623151
    DOI
    10.1016/j.ydbio.2009.09.031
    PubMed ID
    19782675
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S0012160609012160
    Type
    Article
    Language
    en
    ISSN
    0012-1606
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ydbio.2009.09.031
    Scopus Count
    Collections
    Biomedical and biological science

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