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dc.contributor.authorOu, Yetaoen
dc.contributor.authorLi, Qingwangen
dc.contributor.authorWang, Jianjieen
dc.contributor.authorLi, Kunen
dc.contributor.authorZhou, Shaoboen
dc.date.accessioned2019-01-29T11:32:01Z
dc.date.available2019-01-29T11:32:01Z
dc.date.issued2014-07-31
dc.identifier.citationOu Y, Li Q, Wang J, Li K, Zhou S (2014) 'Antitumor and apoptosis induction effects of paeonol on mice bearing EMT6 breast carcinoma', Biomolecules & Therapeutics, 22 (4), pp.341-6.en
dc.identifier.issn1976-9148
dc.identifier.pmid25143814
dc.identifier.doi10.4062/biomolther.2013.106
dc.identifier.urihttp://hdl.handle.net/10547/623115
dc.description.abstractPaeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated the mechanism by giving treatments of placebo, cyclophosphamide, paeonol of 150 and 300 mg/kg to 4 groups of mice bearing EMT6 breast cancer. Apoptosis in tumor cells were confirmed by morphology analysis, including hematoxylin, eosin staining and TUNEL staining. The results showed that the weight of EMT6 breast tumor was significantly reduced in the groups treated with both 150 and 300 mg/kg of paeonol. Immunohistochemical and Western blot results showed that the expression of Bcl-2 was down-regulated while the expression of Bax, caspase 8 and caspase 3 was up-regulated respectively. These results suggest that paeonol exhibits antitumor effects and the mechanism of the inhibition is via induction of apoptosis, regulation of Bcl-2 and Bax expression, and activation of caspase 8 and caspase 3.
dc.language.isoenen
dc.publisherKorean Society of Applied Pharmacologyen
dc.relation.urlhttp://www.biomolther.org/journal/view.html?volume=22νmber=4&spage=341&year=2014en
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131527/en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectapoptosisen
dc.subjectpathwayen
dc.subjectpaeonolen
dc.subjectbreast canceren
dc.titleAntitumor and apoptosis induction effects of paeonol on mice bearing EMT6 breast carcinomaen
dc.typeArticleen
dc.contributor.departmentYanshan Universityen
dc.contributor.departmentNorthwest A&F Universityen
dc.contributor.departmentJiamusi Universityen
dc.contributor.departmentUniversity of Bedfordshireen
dc.identifier.journalBiomolecules & Therapeuticsen
dc.identifier.pmcidPMC4131527
dc.date.updated2019-01-29T11:25:02Z
dc.description.noteoa article
html.description.abstractPaeonol is a major phenolic micromolecular component of Moutan cortex Radicis, a traditional Chinese Medicine. It has shown antitumor effects in previous studies; however, the underlying mechanisms remain unknown. This study investigated the mechanism by giving treatments of placebo, cyclophosphamide, paeonol of 150 and 300 mg/kg to 4 groups of mice bearing EMT6 breast cancer. Apoptosis in tumor cells were confirmed by morphology analysis, including hematoxylin, eosin staining and TUNEL staining. The results showed that the weight of EMT6 breast tumor was significantly reduced in the groups treated with both 150 and 300 mg/kg of paeonol. Immunohistochemical and Western blot results showed that the expression of Bcl-2 was down-regulated while the expression of Bax, caspase 8 and caspase 3 was up-regulated respectively. These results suggest that paeonol exhibits antitumor effects and the mechanism of the inhibition is via induction of apoptosis, regulation of Bcl-2 and Bax expression, and activation of caspase 8 and caspase 3.


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