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    ZAG and a potential role in systemic lipid homeostastis: examining the evidence from in vitro human studies and patients with chronic illness

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    Authors
    McDermott, Lindsay C.
    Jadoon, Ayesha
    Cunningham, Phil
    Issue Date
    2012-08-31
    Subjects
    n-3 polyunsaturated fatty acids
    C700 Molecular Biology, Biophysics and Biochemistry
    
    Metadata
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    Abstract
    ZAG, a 42 kDa ubiquitously expressed soluble and secreted protein, consists of an MHC-like fold and binds fatty acids with an affinity similar to that of albumin. In human adipocytes, cytoplasmic and secreted ZAG appear inversely related to fat mass. Immunoblotting and biochemical measurements of human cachectic adipocytes and plasma suggest that ZAG’s lipolytic function may be mediated by βIAR. Plasma ZAG correlates with cholesterol in human populations, as does its single nucleotide polymorphism rs4215, which also associates with obesity. Biochemical and human genetic data, in vitro experiments and theoretical data imply that adipocyte ZAG’s expression is regulated by PPAR-γ and glucocorticoids. Cell biological experiments and data from human tissue indicate that ZAG may induce fatty-acid oxidation in skeletal muscle. Overall, these findings suggest ZAG’s participation in systemic lipid homeostasis. Understanding the molecular mechanisms behind ZAG’s in vivo behavior potentially allows for rational drug design to control body fat mass.
    Citation
    McDermott L, Jadoon A, Cunningham P (2012) 'ZAG and a potential role in systemic lipid homeostastis: examining the evidence from in vitro human studies and patients with chronic illness', Clinical Lipidology, 7 (4), pp.409-417.
    Publisher
    Future Medicine
    Journal
    Clinical Lipidology
    URI
    http://hdl.handle.net/10547/622690
    DOI
    10.2217/clp.12.45
    Additional Links
    https://www.tandfonline.com/doi/10.2217/clp.12.45
    Type
    Article
    Language
    en
    ISSN
    1758-4299
    ae974a485f413a2113503eed53cd6c53
    10.2217/clp.12.45
    Scopus Count
    Collections
    Biomedical and biological science

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