Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression
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Authors
Jadoon, AyeshaChiu, Chih-Chiang
McDermott, Lindsay C.
Cunningham, Phil
Frangou, Sophia
Chang, Ching-Jui
Sun, I-Wen
Liu, Shen-Ing
Lu, Mong-Liang
Su, Kuan-Pin
Huang, Shih-Yi
Stewart, Robert
Affiliation
King's College LondonTaipei City Hospital
Taipei Medical University
Cathay General Hospital, Taipei
Mackay Memorial Hospital, Taipei
China Medical University
Issue Date
2012-02-28Subjects
n-3 polyunsaturated fatty acidsdepression
anxiety
ageing
C700 Molecular Biology, Biophysics and Biochemistry
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BACKGROUNDS: Depression in late life often follows a chronic course with residual depressive and anxiety symptoms. Levels of omega-3 polyunsaturated fatty acids (PUFAs) have been found to be depleted in people with major depression in the acute stage. Additionally, lower omega-3 PUFA levels have been suggested to be associated with anxiety. The aim of this study was to investigate whether PUFAs levels (omega-3 or omega-6) are correlated with residual depressive or anxiety symptoms in older people with previous depression. METHODS: Participants aged 60 years or over with previous major depression in remission were enrolled from outpatient psychiatric services of four hospitals. Participants with residual depressive symptoms were defined as the Hamilton Depression Rating Scale (HDRS) scores>5, and those with anxiety were defined as sum of scores for the two anxiety subscale of HDRS≧2. The levels of fatty acids in erythrocyte membranes and in plasma were measured separately by gas chromatography. RESULTS: One hundred and thirty two older people with previous major depression (mean age of 68 years, range 60-86 years) were analyzed. Erythrocyte membrane linoleic acid levels had a curvilinear association with depressive symptoms and anxiety symptoms. Plasma linoleic acid levels were found to have a negative linear relationship with depressive symptoms. No significant associations were found between any omega-3 fatty acid level and depressive or anxiety symptoms. CONCLUSION: Linoleic acid levels may be a possible biomarker for residual depression and anxiety in older people with previous depression. Possible clinical applications need further investigation.Citation
Jadoon A, Chiu CC, McDermott L, Cunningham P, Frangou S, Chang CJ, Sun I-W, Liu S-I, Lu M-L, Su K-P, Huang S-Y, Robert S (2012) 'Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression', Journal of Affective Disorders, 136 (3), pp.918-925.Publisher
ElsevierJournal
Journal of Affective DisordersPubMed ID
22113178Type
ArticleLanguage
enISSN
0165-0327ae974a485f413a2113503eed53cd6c53
10.1016/j.jad.2011.09.007
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