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    Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression

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    Authors
    Jadoon, Ayesha
    Chiu, Chih-Chiang
    McDermott, Lindsay C.
    Cunningham, Phil
    Frangou, Sophia
    Chang, Ching-Jui
    Sun, I-Wen
    Liu, Shen-Ing
    Lu, Mong-Liang
    Su, Kuan-Pin
    Huang, Shih-Yi
    Stewart, Robert
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    Affiliation
    King's College London
    Taipei City Hospital
    Taipei Medical University
    Cathay General Hospital, Taipei
    Mackay Memorial Hospital, Taipei
    China Medical University
    Issue Date
    2012-02-28
    Subjects
    n-3 polyunsaturated fatty acids
    depression
    anxiety
    ageing
    C700 Molecular Biology, Biophysics and Biochemistry
    
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    Abstract
    BACKGROUNDS: Depression in late life often follows a chronic course with residual depressive and anxiety symptoms. Levels of omega-3 polyunsaturated fatty acids (PUFAs) have been found to be depleted in people with major depression in the acute stage. Additionally, lower omega-3 PUFA levels have been suggested to be associated with anxiety. The aim of this study was to investigate whether PUFAs levels (omega-3 or omega-6) are correlated with residual depressive or anxiety symptoms in older people with previous depression. METHODS: Participants aged 60 years or over with previous major depression in remission were enrolled from outpatient psychiatric services of four hospitals. Participants with residual depressive symptoms were defined as the Hamilton Depression Rating Scale (HDRS) scores>5, and those with anxiety were defined as sum of scores for the two anxiety subscale of HDRS≧2. The levels of fatty acids in erythrocyte membranes and in plasma were measured separately by gas chromatography. RESULTS: One hundred and thirty two older people with previous major depression (mean age of 68 years, range 60-86 years) were analyzed. Erythrocyte membrane linoleic acid levels had a curvilinear association with depressive symptoms and anxiety symptoms. Plasma linoleic acid levels were found to have a negative linear relationship with depressive symptoms. No significant associations were found between any omega-3 fatty acid level and depressive or anxiety symptoms. CONCLUSION: Linoleic acid levels may be a possible biomarker for residual depression and anxiety in older people with previous depression. Possible clinical applications need further investigation.
    Citation
    Jadoon A, Chiu CC, McDermott L, Cunningham P, Frangou S, Chang CJ, Sun I-W, Liu S-I, Lu M-L, Su K-P, Huang S-Y, Robert S (2012) 'Associations of polyunsaturated fatty acids with residual depression or anxiety in older people with major depression', Journal of Affective Disorders, 136 (3), pp.918-925.
    Publisher
    Elsevier
    Journal
    Journal of Affective Disorders
    URI
    http://hdl.handle.net/10547/622688
    DOI
    10.1016/j.jad.2011.09.007
    PubMed ID
    22113178
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S0165032711005337?via=ihub
    Type
    Article
    Language
    en
    ISSN
    0165-0327
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jad.2011.09.007
    Scopus Count
    Collections
    Biomedical and biological science

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