Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase
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Issue Date
2014-04-08Subjects
metabolismmathematics
computational imaging
arachidonic acid
metabolism
protein–protein interactions
leukotrienes
lipoxygenase
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Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition.We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.Citation
Jadoon A, Cunningham P, McDermott LC (2014) 'Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase', Placenta, 35 (6), pp.422-424.Publisher
ElsevierJournal
PlacentaType
ArticleLanguage
enISSN
0143-4004Sponsors
EPSRC DTA award EP/P504961/1ae974a485f413a2113503eed53cd6c53
10.1016/j.placenta.2014.03.024