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dc.contributor.authorFan, Hua-Yingen
dc.contributor.authorSun, Lien
dc.contributor.authorLi, Xiao-xiaoen
dc.contributor.authorZhou, Shaoboen
dc.contributor.authorLiang, Jun-chengen
dc.contributor.authorYan, Ben-yongen
dc.contributor.authorLi, Yuen
dc.contributor.authorDeng, Yan-pingen
dc.date.accessioned2017-09-25T11:38:51Z
dc.date.available2017-09-25T11:38:51Z
dc.date.issued2014-07-10
dc.identifier.citationFan HY, Sun L, Li XX, Zhou SB, Liang JC, Yan BY, Li Y, Deng YP (2014) 'Effects of Jitai tablet, a traditional Chinese medicine, on plasma adrenocorticotropic hormone and cortisol levels in Heroin addicts during abstinence', Journal of Alternative and Complementary Medicine, 20 (7), pp.527-534.en
dc.identifier.issn1075-5535
dc.identifier.pmid24786196
dc.identifier.doi10.1089/acm.2012.0804
dc.identifier.urihttp://hdl.handle.net/10547/622231
dc.description.abstractObjectives: To investigate the changes in adrenocorticotropic hormone (ACTH) and cortisol in heroin addicts given Jitai tablet treatment during abstinence. Design: Double-blind, randomized, placebo-controlled clinical trial. Settings/Location: Drug Rehabilitation Bureau of Shanghai Police, China. Participants: 99 volunteers, including 69 heroin addicts and 30 healthy volunteers. Interventions: 69 heroin addicts randomly divided into two groups: the Jitai tablet group, which comprised 34 heroin addicts given Jitai tablet treatment during abstinence, and the placebo group, which comprised 35 heroin addicts given placebo. A control group consisted of 30 sex- and age-matched healthy volunteers. Outcome Measures: ACTH and cortisol in plasma were measured in all groups at baseline and in the Jitai tablet and placebo groups on the third, seventh, and 14th days of abstinence. Results: Levels of both ACTH ( p < .01) and cortisol ( p < .001) were significantly higher in heroin addicts at baseline than in the healthy volunteers. Jitai tablet treatment restored plasma cortisol levels to normal more rapidly than did placebo treatment ( p < .05), but not ACTH levels. A positive correlation between ACTH and cortisol values at baseline ( p < .01) was also found with withdrawal symptom scores and daily dosages of heroin. Conclusions: Heroin addicts could respond to Jitai tablets through changes in the hypothalamus-pituitaryadrenal axis.
dc.language.isoenen
dc.publisherMary Ann Lieberten
dc.relation.urlhttp://online.liebertpub.com/doi/abs/10.1089/acm.2012.0804en
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF
dc.subjecthealthen
dc.subjectJitaien
dc.subjecttraditional Chinese medicineen
dc.subjectheroinen
dc.subjectdrug addictionen
dc.titleEffects of Jitai tablet, a traditional Chinese medicine, on plasma adrenocorticotropic hormone and cortisol levels in Heroin addicts during abstinenceen
dc.typeArticleen
dc.contributor.departmentPeking Universityen
dc.contributor.departmentUniversity of Bedfordshireen
dc.contributor.departmentDrug Rehabilitation Bureau of Shanghai Policeen
dc.identifier.journalJournal of Alternative and Complementary Medicineen
dc.date.updated2017-09-25T11:16:39Z
html.description.abstractObjectives: To investigate the changes in adrenocorticotropic hormone (ACTH) and cortisol in heroin addicts given Jitai tablet treatment during abstinence. Design: Double-blind, randomized, placebo-controlled clinical trial. Settings/Location: Drug Rehabilitation Bureau of Shanghai Police, China. Participants: 99 volunteers, including 69 heroin addicts and 30 healthy volunteers. Interventions: 69 heroin addicts randomly divided into two groups: the Jitai tablet group, which comprised 34 heroin addicts given Jitai tablet treatment during abstinence, and the placebo group, which comprised 35 heroin addicts given placebo. A control group consisted of 30 sex- and age-matched healthy volunteers. Outcome Measures: ACTH and cortisol in plasma were measured in all groups at baseline and in the Jitai tablet and placebo groups on the third, seventh, and 14th days of abstinence. Results: Levels of both ACTH ( p < .01) and cortisol ( p < .001) were significantly higher in heroin addicts at baseline than in the healthy volunteers. Jitai tablet treatment restored plasma cortisol levels to normal more rapidly than did placebo treatment ( p < .05), but not ACTH levels. A positive correlation between ACTH and cortisol values at baseline ( p < .01) was also found with withdrawal symptom scores and daily dosages of heroin. Conclusions: Heroin addicts could respond to Jitai tablets through changes in the hypothalamus-pituitaryadrenal axis.


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