Chronic probiotic supplementation and its effects on eHsp72 and LPS concentration following a desert-based ultramarathon
extracellular heat shock protein 72
C600 Sports Science
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AbstractThis study investigated the effect of 12wk probiotic supplementation on the Lipopolysaccharides (LPS) and extracellular-heat-shock-protein 72 (eHsp72) response to a 7d ultra-endurance event (249.4km) in extreme heat [(average temperature ~38°C) Marathon des Sables (MDS) 2015]. Thirty-two (6 female) competitors were randomly allocated to receive probiotic, probiotic + glutamine, or no supplementation for 12wk prior to the MDS. Blood samples were collected on two occasions prior to the race [12wk (baseline) and 7d pre-race], and two further occasions post-race (6-8h and 7d post-race). Plasma eHsp72 and LPS concentrations were determined using ELISAs; V O was recorded at baseline and pre-race. A significant increase in overall mean V O was observed from baseline to pre-race (p<0.05), however no difference was found between groups (p>0.05). Overall mean post-race eHsp72 concentration was significantly increased (p<0.05) by 124% from baseline, there was no significant effect of group on eHsp72 concentration at any time point (p>0.05). There was no significant change in LPS concentration from baseline to post-race in all groups (p>0.05), no difference in LPS concentration was observed between groups at any time (p>0.05). This study indicates an ineffective role of PRO and PGLn supplementation on LPS translocation and eHsp72 response to ultramarathon performance in extreme heat.
CitationMarshall, H. (2015). 'Chronic Probiotic Supplementation and its Effects on eHsp72 and LPS Concentration Following a Desert-based Ultramarathon'. MSc by Research Thesis. University of Bedfordshire.
PublisherUniversity of Bedfordshire
TypeThesis or dissertation
DescriptionA thesis submitted to the University of Bedfordshire in partial fulfillment of the requirements for the degree of Masters of Science by Research
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