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Genome sequence of the mycotoxigenic crop pathogen Fusarium proliferatum strain ITEM 2341 from date palmFusarium proliferatum is a widely distributed fungal pathogen associated with more than 26 crop species important in global food security. Its strong mycotoxigenic capability with potential impacts on human and animal health is well recognized. In this work, we report the draft genome sequence of F. proliferatum strain ITEM 2341, originally isolated from date palm, providing a platform for further comparative and functional genomic investigations.