Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification
AuthorsMehta, Sanjeev R.
Louise Thomas, Elizabeth
Crofton, Mary E.
Morin, Stanislas X.
Goldstone, Anthony P.
Johnston, Desmond G.
Bell, Jimmy D.
Taylor-Robinson, Simon D.
MetadataShow full item record
AbstractAim: The increasing prevalence of fatty liver disease requires routine assessment methods. Proton magnetic resonance spectroscopy (1H MRS) is increasingly used for steatosis measurement, but due to cost, is unlikely to become a widely-used screening tool. Ultrasound is cheaper and more widely available, although subject to observer variability. Our aim was to determine the sensitivity and specificity of ultrasound against 1H MRS, using MRS as a gold standard, for the detection and quantification of hepatic fat content. Methods: Fifty adults participated (43 men, seven women) in this study. Hepatic steatosis was assessed by ultrasound and 1H MRS. Images were graded by two independent radiologists to classify severity and distribution of liver fat. Results: Ultrasound detected liver fat infiltration in 82% of cases measurable by 1H MRS, while liver fat was detectable in 44% of cases graded absent by ultrasound. Ultrasound grading was subjective, with the radiologists in agreement in 53% of cases (κ = 0.39, P = 0.002). Considerable overlap in intrahepatocellular lipid content was observed between different grades: absent (0.0–1.58%), mild (2.2–16.2%), moderate (4.9–26.7%) and severe (8.1–76.8%) steatosis. Ultrasound could not detect liver fat levels below 2% as measured by 1H MRS Conclusion: Ultrasound is less sensitive than 1H MRS in detecting very low levels of liver fat content, but is sensitive to fatty infiltration greater than 2%. There is a tendency of higher ultrasound grades to correlate with higher degrees of fatty infiltration, although some overlap exists. Our findings are still consistent with ultrasound being useful as a low cost screening tool.
CitationMehta, S.R. et al (2010) 'Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification'. Hepatology Research 40 (4):399
- The use of ultrasound to diagnose hepatic steatosis in type 2 diabetes: intra- and interobserver variability and comparison with magnetic resonance spectroscopy.
- Authors: Williamson RM, Perry E, Glancy S, Marshall I, Gray C, Nee LD, Hayes PC, Forbes S, Frier BM, Johnston GI, Lee AJ, Reynolds RM, Price JF, Strachan MW, Edinburgh Type 2 Diabetes Study investigators.
- Issue date: 2011 May
- Validity of ultrasonography to assess hepatic steatosis compared to magnetic resonance spectroscopy as a criterion method in older adults.
- Authors: De Lucia Rolfe E, Brage S, Sleigh A, Finucane F, Griffin SJ, Wareham NJ, Ong KK, Forouhi NG
- Issue date: 2018
- A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS versus liver histology in non-alcoholic fatty liver disease.
- Authors: Idilman IS, Keskin O, Celik A, Savas B, Elhan AH, Idilman R, Karcaaltincaba M
- Issue date: 2016 Mar
- Ultrasound hepatic/renal ratio and hepatic attenuation rate for quantifying liver fat content.
- Authors: Zhang B, Ding F, Chen T, Xia LH, Qian J, Lv GY
- Issue date: 2014 Dec 21
- Accuracy of Liver Fat Quantification With Advanced CT, MRI, and Ultrasound Techniques: Prospective Comparison With MR Spectroscopy.
- Authors: Kramer H, Pickhardt PJ, Kliewer MA, Hernando D, Chen GH, Zagzebski JA, Reeder SB
- Issue date: 2017 Jan