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    Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes

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    Authors
    Watson, R.A.
    Pride, N.B.
    Thomas, E. Louise
    Fitzpatrick, Julie
    Durighel, Giuliana
    McCarthy, John
    Morin, Stanislas X.
    Ind, P.W.
    Bell, Jimmy D.
    Affiliation
    National Heart and Lung Institute
    Imperial College London
    Issue Date
    2010-03-18
    Subjects
    magnetic resonance imaging
    restricted total lung capacity
    lung capacity
    mediastinal volume
    MRI
    
    Metadata
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    Abstract
    Restriction of total lung capacity (TLC) is found in some obese subjects, but the mechanism is unclear. Two hypotheses are as follows: 1) increased abdominal volume prevents full descent of the diaphragm; and 2) increased intrathoracic fat reduces space for full lung expansion. We have measured total intrathoracic volume at full inflation using magnetic resonance imaging (MRI) in 14 asymptomatic obese men [mean age 52 yr, body mass index (BMI) 35–45 kg/m2] and 7 control men (mean age 50 yr, BMI 22–27 kg/m2). MRI volumes were compared with gas volumes at TLC. All measurements were made with subjects supine. Obese men had smaller functional residual capacity (FRC) and FRC-to-TLC ratio than control men. There was a 12% predicted difference in mean TLC between obese (84% predicted) and control men (96% predicted). In contrast, differences in total intrathoracic volume (MRI) at full inflation were only 4% predicted TLC (obese 116% predicted TLC, control 120% predicted TLC), because mediastinal volume was larger in obese than in control [heart and major vessels (obese 1.10 liter, control 0.87 liter, P = 0.016) and intrathoracic fat (obese 0.68 liter, control 0.23 liter, P < 0.0001)]. As a consequence of increased mediastinal volume, intrathoracic volume at FRC in obese men was considerably larger than indicated by the gas volume at FRC. The difference in gas volume at TLC between the six obese men with restriction, TLC < 80% predicted (OR), and the eight obese men with TLC > 80% predicted (ON) was 26% predicted TLC. Mediastinal volume was similar in OR (1.84 liter) and ON (1.73 liter), but total intrathoracic volume was 19% predicted TLC smaller in OR than in ON. We conclude that the major factor restricting TLC in some obese men was reduced thoracic expansion at full inflation.
    Citation
    Watson, R.A. et al (2010) 'Reduction of total lung capacity in obese men: comparison of total intrathoracic and gas volumes'. Journal of Applied Physiology 108 (6):1605
    Publisher
    American Physiological Society
    Journal
    Journal of Applied Physiology
    URI
    http://hdl.handle.net/10547/594732
    DOI
    10.1152/japplphysiol.01267.2009
    PubMed ID
    20299612
    PubMed Central ID
    PMC2886677
    Additional Links
    http://jap.physiology.org/cgi/doi/10.1152/japplphysiol.01267.2009
    Type
    Article
    Language
    en
    ISSN
    8750-7587
    1522-1601
    ae974a485f413a2113503eed53cd6c53
    10.1152/japplphysiol.01267.2009
    Scopus Count
    Collections
    Muscle Cellular and Molecular Physiology

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