An elevation of resting metabolic rate with declining health in nonagenarians may be associated with decreased muscle mass and function in women and men, respectively.
Authors
Kim, SangkyuWelsh, David A.
Ravussin, Eric
Welsch, Michael A.
Cherry, Katie E.
Myers, Leann
Jazwinski, S. Michal
Affiliation
Tulane University Health Sciences CenterLouisiana State University Health Sciences Center
Pennington Biomedical Research Center
Louisiana State University
Issue Date
2014-06
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Show full item recordAbstract
Previously, we showed that FI34, a frailty index based on 34 health and function ability variables, is heritable and a reliable phenotypic indicator of healthy aging. We have now examined the relationship between major components of energy expenditure and the FI34 in participants of the Louisiana Healthy Aging Study. Resting metabolic rate was associated with FI34, even after adjustment for fat-free mass, fat mass, age, sex, thyroid hormones, and insulin-like growth factor 1 levels, in multiple regression analyses. In contrast, there was no association between total daily energy expenditure and FI34. Circulating creatine phosphokinase, a clinical marker of muscle damage, was also significantly associated with FI34. However, these associations of resting metabolic rate with FI34 were restricted to the oldest old (≥90 years) and absent in younger age groups. In oldest old men, the association of FI34 with creatine phosphokinase persisted, whereas in the oldest old women, only the association with resting metabolic rate pertained with the appearance of an effect of body size and composition. These results point toward an increasing metabolic burden for the maintenance of homeodynamics as health declines in nonagenarians, and this has implications for contraction of metabolic reserve that may potentially accelerate the path to disability.Citation
Kim, S. et al (2014) 'An elevation of resting metabolic rate with declining health in nonagenarians may be associated with decreased muscle mass and function in women and men, respectively' J. Gerontol. A Biol. Sci. Med. Sci. 69 (6):650-6Publisher
Oxford University PressPubMed ID
24162336PubMed Central ID
PMC4022095Additional Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022095/http://biomedgerontology.oxfordjournals.org/content/69/6/650.short
Type
ArticleLanguage
enISSN
1758-535Xae974a485f413a2113503eed53cd6c53
10.1093/gerona/glt150
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