TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy
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Authors
Baumgarten, AnnaBang, Claudia
Tschirner, Anika
Engelmann, Anke
Adams, Volker
von Haehling, Stephan
Doehner, Wolfram
Pregla, Reinhard
Anker, Markus S.
Blecharz, Kinga
Meyer, Rudolf
Hetzer, Roland
Anker, Stefan D.
Thum, Thomas
Springer, Jochen
Affiliation
Charité Medical SchoolMedical School Hannover
Heart Center Leipzig
German Heart Center Berlin
IRCCS San Raffaele
University of East Anglia
Issue Date
2013-09-30
Metadata
Show full item recordAbstract
The transcription factor TWIST1 has been described to regulate the microRNA (miR)-199/214 cluster. Genetic disruption of TWIST1 resulted in a cachectic phenotype and early death of the knock-out mice. This might be connected to the activity of the ubiquitin-proteasome-system (UPS), as miR-199a has been suggested to regulate the ubiquitin E2 ligases Ube2i and Ube2g1.Citation
Baumgarten, A. et al (2013) 'TWIST1 regulates the activity of ubiquitin proteasome system via the miR-199/214 cluster in human end-stage dilated cardiomyopathy' Int. J. Cardiol. 168 (2):1447-52Publisher
ElsevierPubMed ID
23360823Additional Links
http://www.sciencedirect.com/science/article/pii/S0167527313000053Type
ArticleLanguage
enISSN
1874-1754ae974a485f413a2113503eed53cd6c53
10.1016/j.ijcard.2012.12.094