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    New targets for the immunotherapy of colon cancer—does reactive disease hold the answer?

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    Authors
    Boncheva, Viktoriya Bogdanova
    Bonney, S.A.
    Brooks, Suzanne E.
    Tangney, Mark
    O'Sullivan, Gerald C.
    Mirnezami, A.
    Guinn, Barbara-Ann
    Issue Date
    2013-03-15
    Subjects
    cancer gene therapy
    immunotherapy
    colon cancer
    reactive disease
    
    Metadata
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    Abstract
    Colorectal cancer (CRC) is one of the most commonly diagnosed cancers in both men and women, posing a serious demographic and economic burden worldwide. In the United Kingdom, CRC affects 1 in every 20 people and it is often detected once well established and after it has spread beyond the bowel (Stage IIA-C and Stage IIIA-C). A diagnosis at such advanced stages is associated with poor treatment response and survival. However, studies have identified two sub-groups of post-treatment CRC patients--those with good outcome (reactive disease) and those with poor outcome (non-reactive disease). We aim to review the state-of-the-art for CRC with respect to the expression of cancer-testis antigens (CTAs) and their identification, evaluation and correlation with disease progression, treatment response and survival. We will also discuss the relationship between CTA expression and regulatory T-cell (Treg) activity to tumorigenesis and tumor immune evasion in CRC and how this could account for the clinical presentation of CRC. Understanding the molecular basis of reactive CRC may help us identify more potent novel immunotherapeutic targets to aid the effective treatment of this disease. In this review, based on our presentation at the 2012 International Society for the Cell and Gene Therapy of Cancer annual meeting, we will summarize some of the most current advances in CTA and CRC research and their influence on the development of novel immunotherapeutic approaches for this common and at times difficult to treat disease.
    Citation
    Boncheva, V., Bonney, S.A.., Brooks, S.E., Tangney, M., O'Sullivan, G.C., Mirnezami, A., Guinn, B.A. (2013) 'New targets for the immunotherapy of colon cancer—does reactive disease hold the answer?' Cancer Gene Therapy 20 (3):157
    Publisher
    Nature Publishing Group
    Journal
    Cancer Gene Therapy
    URI
    http://hdl.handle.net/10547/578857
    DOI
    10.1038/cgt.2013.5
    Additional Links
    http://www.nature.com/doifinder/10.1038/cgt.2013.5
    Type
    Article
    Language
    en
    ISSN
    0929-1903
    1476-5500
    ae974a485f413a2113503eed53cd6c53
    10.1038/cgt.2013.5
    Scopus Count
    Collections
    Biomedicine and Nutrition Research Group

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