Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells
| dc.contributor.author | Chaudhry, Zahara Latif | en_GB |
| dc.contributor.author | Ahmed, Bushra Y. | en_GB |
| dc.date.accessioned | 2013-09-23T11:45:31Z | en |
| dc.date.available | 2013-09-23T11:45:31Z | en |
| dc.date.issued | 2012 | en |
| dc.identifier.citation | Chaudhry, Z.L. and Ahmed, B.Y. (2012) 'Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells', Neurological Research 35(4) 435-440 | en_GB |
| dc.identifier.issn | 0161-6412 | en |
| dc.identifier.doi | 10.1179/1743132812Y.0000000135a | en |
| dc.identifier.uri | http://hdl.handle.net/10547/302101 | en |
| dc.description.abstract | The purpose of the study was to establish a suitable model to study Parkinson’s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN. | |
| dc.language.iso | en | en |
| dc.publisher | Maney Publishing | en_GB |
| dc.relation.url | http://www.ingentaconnect.com/content/maney/nres/pre-prints/1743132812Y.0000000135a | en_GB |
| dc.rights | Archived with thanks to Neurological Research | en_GB |
| dc.subject | dopaminergic neuron | en_GB |
| dc.subject | caspase | en_GB |
| dc.subject | ReNcell VM | en_GB |
| dc.subject | Parkinson's disease | en_GB |
| dc.title | Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells | en |
| dc.type | Article | en |
| dc.identifier.journal | Neurological Research | en_GB |
| html.description.abstract | The purpose of the study was to establish a suitable model to study Parkinson’s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN. |