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    Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells

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    Authors
    Chaudhry, Zahara Latif
    Ahmed, Bushra Y.
    Issue Date
    2012
    Subjects
    dopaminergic neuron
    caspase
    ReNcell VM
    Parkinson's disease
    
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    Abstract
    The purpose of the study was to establish a suitable model to study Parkinson’s disease (PD) pathogenesis in differentiated dopaminergic neurons (dDCN). The specific aim was to demonstrate the involvement of the caspase family and to identify specific caspases which are activated by 6-hydroxydopamine (6OHD) treatment leading to death of dDCN.
    Citation
    Chaudhry, Z.L. and Ahmed, B.Y. (2012) 'Caspase-2 and caspase-8 trigger caspase-3 activation following 6-OHDA-induced stress in human dopaminergic neurons differentiated from ReNVM stem cells', Neurological Research 35(4) 435-440
    Publisher
    Maney Publishing
    Journal
    Neurological Research
    URI
    http://hdl.handle.net/10547/302101
    DOI
    10.1179/1743132812Y.0000000135a
    Additional Links
    http://www.ingentaconnect.com/content/maney/nres/pre-prints/1743132812Y.0000000135a
    Type
    Article
    Language
    en
    ISSN
    0161-6412
    ae974a485f413a2113503eed53cd6c53
    10.1179/1743132812Y.0000000135a
    Scopus Count
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    Cell and Cryobiology Research Group

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