Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation
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Authors
Tokuda, MasaakiAhmed, Bushra Y.
Lu, Yun-Fei
Matsui, Hideki
Miyamoto, Osamu
Yamaguchi, Fuminori
Konishi, Ryoji
Hatase, Osamu
Issue Date
1997
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Multifunctional Ca2+/calmodulin-dependent protein kinases (CaMKs) are thought to be involved in the induction of long-term potentiation (LTP). In the present study, LTP was induced by theta burst stimulation in the Schaffer collateral area of the stratum radiatum in the hippocampal CA1 region of the rat hippocampus. LTP-induced and control hippocampal slices were studied by Western blot and immunohistochemical analyses using CaMK-I, -II and -IV antibodies. Increased amounts of all three CaMKs were found in LTP-induced hippocampal slices as indicated by Western blot as well as by the density of their immunoreactivity. Our data clearly shows that not only CaMK-II but also CaMK-I and -IV contribute to synaptic plasticity formed in LTP.Citation
Tokuda M., Ahmed B. Y., Miyamoto O., Lu Y-F., Matsui H., and Hatase O. (1997) 'Involvement of calmodulin-dependent protein kinases-I and -IV in long-term potentiation', Brain Research, 755(1),pp.162-166Publisher
ElsevierJournal
Brain ResearchAdditional Links
http://linkinghub.elsevier.com/retrieve/pii/S0006899397001893Type
ArticleLanguage
enISSN
0006-8993ae974a485f413a2113503eed53cd6c53
10.1016/S0006-8993(97)00189-3