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    Expression and subcellular localization of multifunctional calmodulin-dependent protein kinases-I, -II and -IV are altered in rat hippocampal CA1 neurons after induction of long-term potentiation

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    Authors
    Ahmed, Bushra Y.
    Yamaguchi, Fuminori
    Tsumura, Toyohiro
    Gotoh, Takaya
    Sugimoto, Katsuyoshi
    Tai, Yuji
    Konishi, Ryoji
    Kobayashi, Ryoji
    Tokuda, Masaaki
    Issue Date
    2000
    Subjects
    long-term potentiation
    calmodulin-dependent protein kinase
    hippocampus
    
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    Abstract
    Long-term potentiation (LTP) is considered to be associated with an increase in expression as well as activity of Ca2+/calmodulin-dependent protein kinases (CaMKs). LTP-induced and control hippocampal slices were studied by immunohistochemical and electronmicroscopic analyses using anti-CaMK-I, -II and -IV antibodies. All three kinases were demonstrated to increase their expression in CA1 neurons. CaMK-I was shown to mainly localize in the cytoplasm of the control and LTP-induced neurons, and a significant increase of immunoreactivity was observed in the latter neurons. A part of CaMK-I was found to translocate to the nuclei of LTP-induced hippocampal CA1 neurons. Direct evidence of the translocation of CaMK-II from cytoplasm to nuclei in LTP was demonstrated by immuno-electronmicroscopy. A significant increase in expression of CaMK-IV in the nuclei was also observed. Our data suggest that all the three CaMKs were actively involved in nuclear Ca2+- signaling in LTP.
    Citation
    Ahmed B. Y., Yamaguchi F., Tsumura T. et al. (2000) 'Expression and subcellular localization of multifunctional calmodulin-dependent protein kinases-I, -II and -IV are altered in rat hippocampal CA1 neurons after induction of long-term potentiation', Neuroscience Letters, 290(2),pp.149-153
    Publisher
    Elsevier
    Journal
    Neuroscience Letters
    URI
    http://hdl.handle.net/10547/302091
    DOI
    10.1016/S0304-3940(00)01347-1
    Additional Links
    http://linkinghub.elsevier.com/retrieve/pii/S0304394000013471
    Type
    Article
    Language
    en
    ISSN
    0304-3940
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0304-3940(00)01347-1
    Scopus Count
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    Cell and Cryobiology Research Group

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