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    Novel retrotransposed imprinted locus identified at human 6p25

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    Authors
    Zhang, Aiping
    Skaar, David A.
    Li, Yue
    Huang, Dale
    Price, Thomas M.
    Murphy, Susan K.
    Jirtle, Randy L.
    Issue Date
    2011
    
    Metadata
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    Abstract
    Differentially methylated regions (DMRs) are stable epigenetic features within or in proximity to imprinted genes. We used this feature to identify candidate human imprinted loci by quantitative DNA methylation analysis. We discovered a unique DMR at the 50-end of FAM50B at 6p25.2. We determined that sense transcripts originating from the FAM50B locus are expressed from the paternal allele in all human tissues investigated except for ovary, in which expression is biallelic. Furthermore, an antisense transcript, FAM50B-AS, was identified to be monoallelically expressed from the paternal allele in a variety of tissues. Comparative phylogenetic analysis showed that FAM50B orthologs are absent in chicken and platypus, but are present and biallelically expressed in opossum and mouse.
    Citation
    Zhang, A., Skaar, D.A., Li,Y, et al. (2011) 'Novel retrotransposed imprinted locus identified at human 6p25', Nucleic Acids Research, 39(13), pp.5388-5400
    Publisher
    Oxford University Press
    Journal
    Nucleic Acids Research
    URI
    http://hdl.handle.net/10547/296168
    DOI
    10.1093/nar/gkr108
    Additional Links
    http://www.nar.oxfordjournals.org/cgi/doi/10.1093/nar/gkr108
    Type
    Article
    Language
    en
    ISSN
    0305-1048
    1362-4962
    ae974a485f413a2113503eed53cd6c53
    10.1093/nar/gkr108
    Scopus Count
    Collections
    Muscle Cellular and Molecular Physiology

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