Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort
Authors
Soubry, AdelheidSchildkraut, Joellen M.
Murtha, Amy
Wang, Frances
Huang, Zhiqing
Bernal, Autumn J.
Kurtzberg, Joanne
Jirtle, Randy L.
Murphy, Susan K.
Hoyo, Cathrine
Affiliation
Duke University Medical CenterIssue Date
2013
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Show full item recordAbstract
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic machinery. Besides in vitro environmental exposures, the possible impact on the reprogramming of methylation profiles at imprinted genes at a much earlier time point, such as during spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to determine associations between preconceptional obesity and DNA methylation profiles in the offspring, particularly at the differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene.Citation
Soubry, A., Schildkraut, J.M., Murtha, A. et al. (2013) 'Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort', BMC medicine, 11 (1) pp.1-10.Publisher
BioMed CentralJournal
BMC medicinePubMed ID
23388414Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/23388414http://www.biomedcentral.com/1741-7015/11/29/
Type
ArticleLanguage
enISSN
1741-7015ae974a485f413a2113503eed53cd6c53
10.1186/1741-7015-11-29
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