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    Daily quadratic trend in basal monocyte expressed HSP72 in healthy human subjects

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    Authors
    Taylor, Lee
    Midgley, Adrian W.
    Chrismas, Bryna C.
    Madden, Leigh A
    Vince, Rebecca V.
    McNaughton, Lars R.
    Affiliation
    University of Hull
    Issue Date
    2010-05
    Subjects
    C600 Sports Science
    
    Metadata
    Show full item record
    Abstract
    The inducible human stress protein heat shock protein 72 (HSP72) performs vital roles within the body at rest and during periods of stress. Recently it was shown over a 24 hour period that basal HSP72 followed a diurnal variation. However, these results and previous literature demonstrate noticeable inter-subject variation in basal HSP72 expression. The notion of intra/inter-day variation in basal HSP72 expression has not been explored in detail. Basal monocyte expressed HSP72 was determined every 3 hours, over a 9 hour period in 12 healthy male subjects (20.2 +/- 1.9 years, 178.7 +/- 5.6 cm, 75.1 +/- 6.0 kg) within a temperature controlled laboratory. A significant quadratic trend was observed for time (F = 26.0, P = 0.001, partial eta(2) = 0.74), where HSP72 decreased between 0800 and 1100 hours (P < 0.001) and then increased between 1100 and 1400 hours (P = 0.015). The main effect for day (F = 2.6, P = 0.14) and the day x time interaction effect (F = 3.9, P = 0.08) were not significant. There was no correlation between serum and monocyte expressed HSP72, with no significant effect for time (F = 2.0, P = 0.21) in serum HSP72 expression. The results support findings by others that basal monocyte expressed HSP72 follows a diurnal variation which incorporates a quadratic trend, which is not compromised by any significant daily variation and that serum HSP72 expression has no endogenous circadian rhythm. The significant quadratic trend in basal monocyte HSP72 expression shown here highlights the need to tightly control variables, such as timing of sample collection, as it is known basal values influence the magnitude of HSP72 expression post-stressor/intervention.
    Citation
    Taylor, L., Midgley, A., Madden, L. A., Vince, R. V., Chrismas., B & McNaughton, L. (2010) 'Daily quadratic trend in basal monocyte expressed HSP72 in healthy human subjects', Amino Acids, 38, pp. 1483-1488.
    Publisher
    Springer
    Journal
    Amino acids
    URI
    http://hdl.handle.net/10547/295130
    DOI
    10.1007/s00726-009-0360-6
    PubMed ID
    19816654
    Additional Links
    http://www.ncbi.nlm.nih.gov/pubmed/19816654
    https://link.springer.com/article/10.1007%2Fs00726-009-0360-6
    Type
    Article
    Language
    en
    ISSN
    1438-2199
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00726-009-0360-6
    Scopus Count
    Collections
    Applied Sport and Exercise Physiology

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