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Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives.

dc.contributor.authorVince, Rebecca V.en_GB
dc.contributor.authorMcNaughton, Lars R.en_GB
dc.contributor.authorTaylor, Leeen_GB
dc.contributor.authorMidgley, Adrian W.en_GB
dc.contributor.authorLaden, Gerarden_GB
dc.contributor.authorMadden, Leigh A.en_GB
dc.date.accessioned2013-07-02T15:18:48Z
dc.date.available2013-07-02T15:18:48Z
dc.date.issued2009-03
dc.identifier.citationVince, R. V., McNaughton, L., Taylor, L., Midgley, A. W., Laden, G. & Madden, L. A. (2009) 'Release of vcam-1 associated endothelial microparticles following simulated scuba dives', European Journal of Applied Physiology, 105 (4), pp. 507-513en_GB
dc.identifier.issn1439-6327
dc.identifier.pmid19002703
dc.identifier.doi10.1007/s00421-008-0927-z
dc.identifier.urihttp://hdl.handle.net/10547/295069
dc.description.abstractMicroparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.
dc.language.isoenen
dc.publisherSpringeren_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19002703en_GB
dc.rightsArchived with thanks to European journal of applied physiologyen_GB
dc.subjectC600 Sports Scienceen_GB
dc.subject.meshCell-Derived Microparticles
dc.subject.meshDiving
dc.subject.meshEndothelium, Vascular
dc.subject.meshFlow Cytometry
dc.subject.meshHumans
dc.subject.meshOxidative Stress
dc.subject.meshVascular Cell Adhesion Molecule-1
dc.titleRelease of VCAM-1 associated endothelial microparticles following simulated SCUBA dives.en
dc.typeArticleen
dc.identifier.journalEuropean journal of applied physiologyen_GB
html.description.abstractMicroparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.


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