Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives.
AuthorsVince, Rebecca V.
McNaughton, Lars R.
Midgley, Adrian W.
Madden, Leigh A.
SubjectsC600 Sports Science
MetadataShow full item record
AbstractMicroparticles (MP) are shed into the circulation from endothelium following activation or apoptosis. Vascular cell adhesion molecule-1 (VCAM-1) is expressed on endothelial cells following activation and here we report quantification of VCAM-1 positive microparticles (VCAM + MP) following simulated SCUBA dives, breathing either air or oxygen. VCAM + MP were quantified pre-dive (09:00 and 13:00) and post-dive (+1, +3 and +15 h) on both air and oxygen dives and compared with control samples taken from the same subjects. VCAM + MP followed a similar trend in all experiments, however both dives caused a change in endothelial state, as measured by VCAM + MP. A significant increase in VCAM + MP was observed 1 h post-air dive relative to the control (p = 0.013), which was not observed after the oxygen dive (p = 0.095). Oxidative stress (TBARS) was correlated with VCAM + MP. Data presented highlights the potential of MP as a biological marker of both endothelial state and decompression illness.
CitationVince, R. V., McNaughton, L., Taylor, L., Midgley, A. W., Laden, G. & Madden, L. A. (2009) 'Release of vcam-1 associated endothelial microparticles following simulated scuba dives', European Journal of Applied Physiology, 105 (4), pp. 507-513