• Login
    View Item 
    •   Home
    • ISPAR Institute for Sport and Physical Activity Research - to April 2016
    • Applied Sport and Exercise Physiology
    • View Item
    •   Home
    • ISPAR Institute for Sport and Physical Activity Research - to April 2016
    • Applied Sport and Exercise Physiology
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UOBREPCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalDepartmentThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalDepartment

    My Account

    LoginRegister

    About

    AboutLearning ResourcesResearch Graduate SchoolResearch InstitutesUniversity Website

    Statistics

    Display statistics

    Microparticle-associated vascular adhesion molecule-1 and tissue factor follow a circadian rhythm in healthy human subjects

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Madden, Leigh A.
    Vince, Rebecca V.
    Sandström, Marie E.
    Taylor, Lee
    McNaughton, Lars R.
    Laden, Gerard
    Issue Date
    2008-05
    Subjects
    C600 Sports Science
    
    Metadata
    Show full item record
    Abstract
    An increased risk of death or severe injury due to late-morning thrombotic events is well established. Tissue factor (TF) is the initiator of the coagulation cascade, and endothelial stresses, coupled with production of pro-coagulant microparticles (MP) are also important factors in loss of haemostasis. TF and vascular cell adhesion molecule-1 (VCAM-1) -positive cell microparticles were assessed periodically over a 24-hour (h) period in healthy human subjects to ascertain if they followed a circadian rhythm. Eleven healthy male subjects were assessed in a temperature-controlled environment with dietary intake consistent between subjects. Blood samples were taken every 4 h by venipuncture, and TF and VCAM-1 positive microparticles were quantified by flow cytometry. A significant circadian rhythm was observed in VCAM-1 MP (p=or<0.0001), and a trend was shown, although not statistically significant (p=0.065) in TF microparticles. A peak was observed at 9 a.m. for VCAM-1 positive MP, followed by a decrease and subsequent peak at 9 p.m. and a minimum at 5 a.m. TF-positive MP followed a strikingly similar trend in both variation and absolute numbers with a delay. A circadian rhythm was observed in VCAM-1 and less so TF-positive MP. This has significant implications in terms of the well known increased risk of cardiovascular thrombotic events matching this data. To our knowledge this is the first such report of quantified measurements of these MP over a 24-h period and the only measurement of a 24-h variation of in-vivo blood-borne TF.
    Citation
    Madden, L. A., Vince, R. V., Sandstrom, M. E., Taylor, L., McNaughton, L. and Laden, G. (2008) 'Microparticle-associated vascular adhesion molecule-i and tissue factor follow a circadian rhythm in healthy human subjects', Thrombosis and Haemostasis, 99, pp. 909-915.
    Publisher
    Schattauer
    Journal
    Thrombosis and haemostasis
    URI
    http://hdl.handle.net/10547/295058
    DOI
    10.1160TH008-01-0030
    PubMed ID
    18449421
    Additional Links
    http://www.ncbi.nlm.nih.gov/pubmed/18449421
    Type
    Article
    Language
    en
    ISSN
    0340-6245
    ae974a485f413a2113503eed53cd6c53
    10.1160TH008-01-0030
    Scopus Count
    Collections
    Applied Sport and Exercise Physiology

    entitlement

    Related articles

    • Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus.
    • Authors: Diamant M, Nieuwland R, Pablo RF, Sturk A, Smit JW, Radder JK
    • Issue date: 2002 Nov 5
    • Increased soluble VCAM-1 serum levels in preeclampsia are not correlated to urinary excretion or circadian blood pressure rhythm.
    • Authors: Heyl W, Heintz B, Reister F, Harwig S, Witte K, Lemmer B, Rath W
    • Issue date: 2005
    • [Detection of tissue factor-positive microparticles and its clinical significance in the haemostatic disorder].
    • Authors: Zhou LL, Han Y, Zhu Q, Hu LP, Zhao SX, Zhu MQ, Dai L, Shen WH, Chen L, Wu DP
    • Issue date: 2012 Aug
    • Microparticle-associated tissue factor activity in patients with acute unprovoked deep vein thrombosis and during the course of one year.
    • Authors: Thaler J, Koppensteiner R, Pabinger I, Ay C, Gremmel T
    • Issue date: 2014 Nov
    • Release of VCAM-1 associated endothelial microparticles following simulated SCUBA dives.
    • Authors: Vince RV, McNaughton LR, Taylor L, Midgley AW, Laden G, Madden LA
    • Issue date: 2009 Mar
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.