G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency

Im, Jae Hong; Tapmeier, Thomas; Balathasan, Lukxmi; Gal, Annamaria; Yameen, Sabira; Hill, Sally; Smart, Sean; Noterdaeme, Olivier; Kelly, Matthew; Brady, Michael; Fu, Weili; Kruse, Karoline; Bernhard, Eric J.; Augustin, Hellmut G.; Muschel, Ruth J.

Abstract

Suppression of neo-angiogenesis is a clinically used anti-tumor strategy with new targets such as angiopoietin-2 (Ang2) being proposed. However, the functions of Ang2 in vascular remodeling, inflammation and tumor growth are not consistent. We examined effect of depletion of host Ang2 on liver colony formation using Ang2 deficient (Ang22/2) mice.

Citation

Im, J.H., Tapmeier, T., Balathasan, L., Gal, A., Yameen, S., Hill, S., Smart, S., Noterdaeme, O., Kelly, M., Brady, M., Fu, W., Kruse, K., Bernhard, E.J., Augustin, H.G. and Muschel, R.J. (2013) 'G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency', International Journal of Cancer, 132(2), pp.315-326.

Type

Article

Language

ISSN

0020-7136

Collections

Cell and Cryobiology Research Group