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    G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency

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    Authors
    Im, Jae Hong
    Tapmeier, Thomas
    Balathasan, Lukxmi
    Gal, Annamaria
    Yameen, Sabira
    Hill, Sally
    Smart, Sean
    Noterdaeme, Olivier
    Kelly, Matthew
    Brady, Michael
    Fu, Weili
    Kruse, Karoline
    Bernhard, Eric J.
    Augustin, Hellmut G.
    Muschel, Ruth J.
    Show allShow less
    Issue Date
    2013
    Subjects
    angiopoietin-2
    neutrophils
    angiogenesis
    vascular leakage
    metastasis
    
    Metadata
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    Abstract
    Suppression of neo-angiogenesis is a clinically used anti-tumor strategy with new targets such as angiopoietin-2 (Ang2) being proposed. However, the functions of Ang2 in vascular remodeling, inflammation and tumor growth are not consistent. We examined effect of depletion of host Ang2 on liver colony formation using Ang2 deficient (Ang22/2) mice.
    Citation
    Im, J.H., Tapmeier, T., Balathasan, L., Gal, A., Yameen, S., Hill, S., Smart, S., Noterdaeme, O., Kelly, M., Brady, M., Fu, W., Kruse, K., Bernhard, E.J., Augustin, H.G. and Muschel, R.J. (2013) 'G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency', International Journal of Cancer, 132(2), pp.315-326.
    Publisher
    Wiley
    Journal
    International Journal of Cancer
    URI
    http://hdl.handle.net/10547/294848
    DOI
    10.1002/ijc.27677
    Additional Links
    http://doi.wiley.com/10.1002/ijc.27677
    Type
    Article
    Language
    en
    ISSN
    0020-7136
    ae974a485f413a2113503eed53cd6c53
    10.1002/ijc.27677
    Scopus Count
    Collections
    Cell and Cryobiology Research Group

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