Abstract
Wound healing in muscle involves the deposition of collagen, but it is not known whether this is achieved by changes in the synthesis or the degradation of collagen. We have used a reliable flooding dose method to measure collagen synthesis rate in vivo in rat abdominal muscle following a surgical incision. Collagen synthesis rate was increased by 480% and 860% on days 2 and 7 respectively after surgery in the wounded muscle compared with an undamaged area of the same muscle. Collagen content was increased by approximately 100% at both day 2 and day 7. These results demonstrate that collagen deposition during wound healing in muscle is achieved entirely by an increase in the rate of collagen synthesis.Citation
Zhou, S., Salisbury, J., Preedy, V.R., Emery, P.W.,and Roy, S.(2013) 'Increased collagen synthesis rate during wound healing in muscle', PLoS ONE, 8(3),e58324.Publisher
Public Library of ScienceJournal
PLoS ONEAdditional Links
http://dx.plos.org/10.1371/journal.pone.0058324Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0058324
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