Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.
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AbstractTo better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure.
CitationGal, A., Sjöblom, T., Fedorova, L., Imreh, S., Beug, H. and Moustakas, A. (2008) 'Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis', 'Oncogene', 27(9),pp. 1218-1230.
PublisherNature Publishing Group
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