Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis.
Abstract
To better understand the dual, tumour-suppressive and tumour-promoting function of transforming growth factor-beta (TGFbeta), we analysed mammary epithelial NMuMG cells in response to short and long-term TGFbeta exposure.Citation
Gal, A., Sjöblom, T., Fedorova, L., Imreh, S., Beug, H. and Moustakas, A. (2008) 'Sustained TGF beta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis', 'Oncogene', 27(9),pp. 1218-1230.Publisher
Nature Publishing GroupJournal
OncogenePubMed ID
17724470Additional Links
http://www.ncbi.nlm.nih.gov/pubmed/17724470http://www.nature.com/onc/journal/v27/n9/full/1210741a.html
Type
ArticleLanguage
enISSN
1476-5594ae974a485f413a2113503eed53cd6c53
10.1038/sj.onc.1210741
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