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    Tetraspanin in oncogenic epithelial-mesenchymal transition

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    Authors
    Muschel, Ruth J.
    Gal, Annamaria
    Issue Date
    2008
    Subjects
    carcinoma
    hepatocellular
    cell differentiation
    epithelial cells
    membrane proteins
    
    Metadata
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    Abstract
    Members of the L6 family of membrane proteins, a branch of the tetraspanin superfamily, are overexpressed in tumor cells from many types of cancers. However, direct evidence of their oncogenic activity has not been previously shown. In this issue of the JCI, Lee et al. demonstrate that overexpression of the tetraspanin superfamily member TM4SF5 in human hepatocellular carcinoma cells causes cellular phenotypic changes that resemble classical descriptions of epithelial-mesenchymal transition (EMT), with some unique aspects. They also show that these TM4SF5-mediated effects trigger tumor formation when these cells are injected into mice. The study implicates TM4SF5, for the first time to our knowledge, in EMT oncogenic pathways of cancer progression.
    Citation
    Muschel, R.J. and Gal, A. (2008) 'Tetraspanin in oncogenic epithelial-mesenchymal transition', Journal of Clinical Investigation, 118 (4),pp.1347-1350.
    Publisher
    American Society for Clinical Investigation
    Journal
    Journal of Clinical Investigation
    URI
    http://hdl.handle.net/10547/294498
    DOI
    10.1172/JCI35308
    Additional Links
    http://www.jci.org/articles/view/35308
    Type
    Article
    Language
    en
    ISSN
    0021-9738
    ae974a485f413a2113503eed53cd6c53
    10.1172/JCI35308
    Scopus Count
    Collections
    Cell and Cryobiology Research Group

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