Show simple item record

dc.contributor.authorYang, Zhenen_GB
dc.contributor.authorDong, Dongen_GB
dc.contributor.authorZhang, Zhaoleien_GB
dc.contributor.authorCrabbe, M. James C.en_GB
dc.contributor.authorWang, Lien_GB
dc.contributor.authorZhong, Yangen_GB
dc.date.accessioned2013-06-13T13:55:34Z
dc.date.available2013-06-13T13:55:34Z
dc.date.issued2012
dc.identifier.citationYang, Z.; Dong, D.; Zhang,Z.; Crabbe, M.J.C.; Wang, L. and Zhong, Y. (2012) 'Preferential regulation of stably expressed genes in the human genome suggests a widespread expression buffering role of microRNAs', BMC Genomics, 13(Suppl.7):S14en_GB
dc.identifier.issn1471-2164
dc.identifier.doi10.1186/1471-2164-13-S7-S14
dc.identifier.urihttp://hdl.handle.net/10547/293924
dc.description.abstractIn this study, we comprehensively explored the stably expressed genes (SE genes) and fluctuant genes (FL genes) in the human genome by a meta-analysis of large scale microarray data. We found that these genes have distinct function distributions. miRNA targets are shown to be significantly enriched in SE genes by using propensity analysis of miRNA regulation, supporting the hypothesis that miRNAs can buffer whole genome expression fluctuation. The expression-buffering effect of miRNA is independent of the target site number within the 3'-untranslated region. In addition, we found that gene expression fluctuation is positively correlated with the number of transcription factor binding sites in the promoter region, which suggests that coordination between transcription factors and miRNAs leads to balanced responses to external perturbations.
dc.language.isoenen
dc.publisherBioMed Centralen_GB
dc.relation.urlhttp://link.springer.com/article/10.1186%2F1471-2164-13-S7-S14en_GB
dc.subjectlife sciencesen_GB
dc.subjectplant geneticsen_GB
dc.subjectgenomicsen_GB
dc.titlePreferential regulation of stably expressed genes in the human genome suggests a widespread expression buffering role of microRNAsen
dc.typeArticleen
dc.identifier.journalBMC Genomicsen_GB
html.description.abstractIn this study, we comprehensively explored the stably expressed genes (SE genes) and fluctuant genes (FL genes) in the human genome by a meta-analysis of large scale microarray data. We found that these genes have distinct function distributions. miRNA targets are shown to be significantly enriched in SE genes by using propensity analysis of miRNA regulation, supporting the hypothesis that miRNAs can buffer whole genome expression fluctuation. The expression-buffering effect of miRNA is independent of the target site number within the 3'-untranslated region. In addition, we found that gene expression fluctuation is positively correlated with the number of transcription factor binding sites in the promoter region, which suggests that coordination between transcription factors and miRNAs leads to balanced responses to external perturbations.


Files in this item

Thumbnail
Name:
bmcgenomics12.pdf
Size:
394.4Kb
Format:
PDF
Description:
Full article

This item appears in the following Collection(s)

Show simple item record