Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling
Authors
van Eijl, SvenZhu, Zheying
Cupitt, John
Gierula, Magdalena
Götz, Christine
Fritsche, Ellen
Edwards, Robert J.
Rodrigues-Lima, Fernando
Issue Date
2012-07-26
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Human skin has the capacity to metabolise foreign chemicals (xenobiotics), but knowledge of the various enzymes involved is incomplete. A broad-based unbiased proteomics approach was used to describe the profile of xenobiotic metabolising enzymes present in human skin and hence indicate principal routes of metabolism of xenobiotic compounds. Several in vitro models of human skin have been developed for the purpose of safety assessment of chemicals. The suitability of these epidermal models for studies involving biotransformation was assessed by comparing their profiles of xenobiotic metabolising enzymes with those of human skin.Citation
Van Eijl, S., Zhu, Z., Cupitt, J., Gierula, M., Gotz, C., Fritsche, E., Edwards, R.J., and Rodrigues-Lima, F. (2012) "Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling", "PLOS One" [Online] 7 (7). Available at: http://dx.plos.org/10.1371/journal.pone.0041721Publisher
Public Library of ScienceJournal
PLOS OneAdditional Links
http://dx.plos.org/10.1371/journal.pone.0041721Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0041721
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