• Login
    View Item 
    •   Home
    • iBEST Institute of Biomedical and Environmental Science and Technology - to April 2016
    • Cell and Cryobiology Research Group
    • View Item
    •   Home
    • iBEST Institute of Biomedical and Environmental Science and Technology - to April 2016
    • Cell and Cryobiology Research Group
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of UOBREPCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalDepartmentThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsPublisherJournalDepartment

    My Account

    LoginRegister

    About

    AboutLearning ResourcesResearch Graduate SchoolResearch InstitutesUniversity Website

    Statistics

    Display statistics

    Striatal histone modifications in models of levodopa-induced dyskinesia.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Nicholas, Anthony P.
    Lubin, Farah D.
    Hallett, Penelope J.
    Vattem, Padmapriya
    Ravenscroft, Paula
    Bezard, Erwan
    Zhou, Shaobo
    Fox, Susan H.
    Brotchie, Jonathan M.
    Sweatt, J. David
    Standaert, David G.
    Show allShow less
    Affiliation
    University of Alabama at Birmingham
    Issue Date
    2008-07
    
    Metadata
    Show full item record
    Abstract
    Despite recent advances in the treatment of Parkinson disease (PD), levodopa remains the most effective and widely used therapy. A major limitation to the use of levodopa is the development of abnormal involuntary movements, termed levodopa-induced dyskinesia (LDID), following chronic levodopa treatment. Since recent studies have suggested that modifications of chromatin structure may be responsible for many long-lasting changes in brain function, we have examined post-translational modifications of striatal histones in two models of LDID: an acute murine model and a chronic macaque monkey model, both exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In the primate model, which closely resembles human LDID, we observed that chronic levodopa and the appearance of LDID was associated with marked deacetylation of histone H4, hyperacetylation and dephosphorylation of histone H3, and enhancement of the phosphorylation of extracellular signal-regulated kinase (ERK). In the murine model of acutely rather than chronically induced LDID, dopamine depletion and levodopa treatment also induced deacetylation of histone H4 and phosphorylation of ERK, but histone H3 exhibited decreased trimethylation and reduced rather than enhanced acetylation. These data demonstrate striking changes in striatal histones associated with the induction of LDID in both animal models. The pattern of changes observed, as well as the behavioral features, differed in the two models. However, both models exhibit marked deacetylation of histone H4, suggesting that inhibitors of H4 deacetylation may be useful in preventing or reversing LDID.
    Citation
    Striatal histone modifications in models of levodopa-induced dyskinesia. 2008, 106 (1):486-494 J. Neurochem.
    Publisher
    Wiley-Blackwell
    Journal
    Journal of neurochemistry
    URI
    http://hdl.handle.net/10547/228773
    DOI
    10.1111/j.1471-4159.2008.05417.x
    PubMed ID
    18410512
    Additional Links
    http://www.ncbi.nlm.nih.gov/pubmed/18410512
    Type
    Article
    Language
    en
    ISSN
    1471-4159
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1471-4159.2008.05417.x
    Scopus Count
    Collections
    Cell and Cryobiology Research Group

    entitlement

    Related articles

    • Genetic inactivation of dopamine D1 but not D2 receptors inhibits L-DOPA-induced dyskinesia and histone activation.
    • Authors: Darmopil S, Martín AB, De Diego IR, Ares S, Moratalla R
    • Issue date: 2009 Sep 15
    • ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice.
    • Authors: Pavón N, Martín AB, Mendialdua A, Moratalla R
    • Issue date: 2006 Jan 1
    • Striatal inhibition of PKA prevents levodopa-induced behavioural and molecular changes in the hemiparkinsonian rat.
    • Authors: Lebel M, Chagniel L, Bureau G, Cyr M
    • Issue date: 2010 Apr
    • Higher free D-aspartate and N-methyl-D-aspartate levels prevent striatal depotentiation and anticipate L-DOPA-induced dyskinesia.
    • Authors: Errico F, Bonito-Oliva A, Bagetta V, Vitucci D, Romano R, Zianni E, Napolitano F, Marinucci S, Di Luca M, Calabresi P, Fisone G, Carta M, Picconi B, Gardoni F, Usiello A
    • Issue date: 2011 Dec
    • Stimulation of cannabinoid receptors reduces levodopa-induced dyskinesia in the MPTP-lesioned nonhuman primate model of Parkinson's disease.
    • Authors: Fox SH, Henry B, Hill M, Crossman A, Brotchie J
    • Issue date: 2002 Nov
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.