Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis.
AffiliationUniversity of Bedfordshire
MetadataShow full item record
AbstractGoodpasture's, or anti-glomerular basement membrane (GBM), disease presents with rapidly progressive glomerulonephritis, caused by autoimmunity to a component of the GBM, the non-collagenous domain of the α3 chain of type IV collagen [α3(IV)NC1]. To investigate the mechanisms of inflammation in glomerulonephritis and to test new approaches to treatment, animal models of glomerulonephritis, termed experimental autoimmune glomerulonephritis (EAG), have been developed in susceptible strains of rats and mice. This review article describes how these models of EAG have been developed over the past three decades, discusses the evidence for the involvement of both humoral and cell-mediated immunity in the induction and pathogenesis of glomerulonephritis in these models and highlights recent, emerging data that have identified potential candidate genes that may control the genetic susceptibility in these different strains of rats and mice. The identification of these susceptibility genes has lead to a better understanding of the genetic basis of this model of anti-GBM disease, which may be relevant to the immunopathogenesis of Goodpasture's disease, and more generally to the progression from autoimmunity to target-organ damage.
CitationReynolds, J. (V) 'Strain differences and the genetic basis of experimental autoimmune anti-glomerular basement membrane glomerulonephritis' International journal of experimental pathology, 92 (3):211-217 Int J Exp Pathol
- The evolution of crescentic nephritis and alveolar haemorrhage following induction of autoimmunity to glomerular basement membrane in an experimental model of Goodpasture's disease.
- Authors: Reynolds J, Moss J, Duda MA, Smith J, Karkar AM, Macherla V, Shore I, Evans DJ, Woodrow DF, Pusey CD
- Issue date: 2003 May
- Genetic susceptibility to experimental autoimmune glomerulonephritis in the Wistar Kyoto rat.
- Authors: Reynolds J, Cook PR, Behmoaras J, Smith J, Bhangal G, Tadros S, Tee J, Salama AD, Evans DJ, Aitman TJ, Cook HT, Pusey CD
- Issue date: 2012 May
- Nasal administration of recombinant rat alpha3(IV)NC1 prevents the development of experimental autoimmune glomerulonephritis in the WKY rat.
- Authors: Reynolds J, Prodromidi EI, Juggapah JK, Abbott DS, Holthaus KA, Kalluri R, Pusey CD
- Issue date: 2005 May
- Experimental autoimmune glomerulonephritis (EAG) induced by homologous and heterologous glomerular basement membrane in two substrains of Wistar-Kyoto rat.
- Authors: Reynolds J, Mavromatidis K, Cashman SJ, Evans DJ, Pusey CD
- Issue date: 1998 Jan
- Segregation of experimental autoimmune glomerulonephritis as a complex genetic trait and exclusion of Col4a3 as a candidate gene.
- Authors: Reynolds J, Cook PR, Ryan JJ, Norsworthy PJ, Glazier AM, Duda MA, Evans DJ, Aitman TJ, Pusey CD
- Issue date: 2002