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    Selenium supplementation and exercise: effect on oxidant stress in overweight adults

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    Authors
    Savory, Louise A.
    Kerr, Catherine J.
    Whiting, Paul
    Finer, Nicholas
    McEneny, Jane
    Ashton, Tony
    Affiliation
    University of Bedfordshire
    Issue Date
    2012-04
    
    Metadata
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    Abstract
    Both obesity and acute high-intensity exercise increase oxidant stress levels. This study investigates whether selenium (Se) supplementation could be a potential effective therapy to reduce obesity-associated oxidant stress and exercise-induced oxidant stress. Ten normal-weight (NW) (22.80 ± 0.41 kg/m(2)) and ten overweight (OW) healthy subjects (28.00 ± 0.81 kg/m(2)) were assessed during a randomized double-blind Se supplementation study (200 µg sodium selenite/day for 3 weeks) with a 3-week placebo control and inversion of treatment periods. Blood levels of lipid hydroperoxide (LH), superoxide dismutase (SOD), erythrocyte glutathione (GSH), and total antioxidant status (TAS), were measured at rest, pre-, and postexercise (30 min 70% VO(2) max before and after treatment (pretreatment (week 0 and 12) and post-treatment (week 3 or 15)). At rest, compared to placebo, Se supplementation had no significant effect on LH, SOD, GSH, and TAS levels. However, Se supplementation decreased LH levels in the OW group, immediately postexercise (-0.25 ± 0.12 µmol/l, P = 0.05) compared to placebo treatment. Postexercise, with or without Se supplementation, no changes in TAS, SOD, and GSH levels were observed in both the NW and OW group. This study has highlighted a potential benefit of Se in reducing LH levels postexercise in OW individuals. Given that oxidant stress is a predictor of coronary events, it is imperative to better understand oxidant stress-related responses to lifestyle factors (in particular "high-risk" population groups) and potential antioxidant therapy.
    Citation
    Savory, L.A., Kerr, C.J., Whiting, P., Finer, N., McEneny, J. and Ashton, T., (2012) 'Selenium supplementation and exercise: effect on oxidant stress in overweight adults', Obesity, 20(4) pp.794-801.
    Publisher
    Wiley
    Journal
    Obesity (Silver Spring, Md.)
    URI
    http://hdl.handle.net/10547/225637
    DOI
    10.1038/oby.2011.83
    PubMed ID
    21593809
    Additional Links
    http://onlinelibrary.wiley.com/doi/10.1038/oby.2011.83/full
    Type
    Article
    Language
    en
    ISSN
    1930-7381
    ae974a485f413a2113503eed53cd6c53
    10.1038/oby.2011.83
    Scopus Count
    Collections
    Physical Activity and Health

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