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    Clinical evaluation of cellular immunotherapy in acute myeloid leukaemia.

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    Authors
    Smits, Evelien L.J.
    Lee, Cindy
    Hardwick, Nicola R.
    Brooks, Suzanne E.
    Van Tendeloo, Viggo F.I.
    Orchard, Kim H.
    Guinn, Barbara-Ann
    Affiliation
    University of Antwerp
    Issue Date
    2011-06
    Subjects
    acute myeloid leukaemia
    clinical immunotherapy
    clinical trials
    
    Metadata
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    Abstract
    Immunotherapy is currently under active investigation as an adjuvant therapy to improve the overall survival of patients with acute myeloid leukaemia (AML) by eliminating residual leukaemic cells following standard therapy. The graft-versus-leukaemia effect observed following allogeneic haematopoietic stem cell transplantation has already demonstrated the significant role of immune cells in controlling AML, paving the way to further exploitation of this effect in optimized immunotherapy protocols. In this review, we discuss the current state of cellular immunotherapy as adjuvant therapy for AML, with a particular focus on new strategies and recently published results of preclinical and clinical studies. Therapeutic vaccines that are being tested in AML include whole tumour cells as an autologous source of multiple leukaemia-associated antigens (LAA) and autologous dendritic cells loaded with LAA as effective antigen-presenting cells. Furthermore, adoptive transfer of cytotoxic T cells or natural killer cells is under active investigation. Results from phase I and II trials are promising and support further investigation into the potential of cellular immunotherapeutic strategies to prevent or fight relapse in AML patients.
    Citation
    Smits, E.L.J., Lee, C., Hardwick, N., Brooks, S.E., Van Tendeloo, V.F.I., Orchard, K., Guinn, B.A. (2011) 'Clinical evaluation of cellular immunotherapy in acute myeloid leukaemia' Cancer immunology, immunotherapy, 60 (6):757-69
    Publisher
    SpringerLink
    Journal
    Cancer immunology, immunotherapy : CII
    URI
    http://hdl.handle.net/10547/224580
    DOI
    10.1007/s00262-011-1022-6
    PubMed ID
    21519825
    Additional Links
    http://www.springerlink.com/content/r12815u123n7x320/?MUD=MP
    Type
    Article
    Language
    en
    ISSN
    1432-0851
    Sponsors
    Leukaemia and Lymphoma Research, Cancer Research U.K.
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00262-011-1022-6
    Scopus Count
    Collections
    Biomedicine and Nutrition Research Group

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