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    Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells.

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    Authors
    Greiner, Jochen
    Bullinger, Lars
    Guinn, Barbara-Ann
    Döhner, Hartmut
    Schmitt, Michael
    Affiliation
    University of Ulm
    Issue Date
    2008-11-15
    Subjects
    acute myeloid leukaemia
    leukaemia associated antigens
    cell proliferation
    
    Metadata
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    Abstract
    Acute myeloid leukemia (AML) is the most common acute leukemia in adults. With intensive induction therapy, most patients younger than 60 years achieve complete remission. However, even if these younger patients were treated intensively, more than 50% will relapse. Clinical results of patients older than 60 years are more unfavorable. Therefore, in all patients with AML, the overall survival is still low. In the past decade, several leukemia-associated antigens (LAA) have been identified in patients with acute myeloid leukemia. BAGE, BCL-2, OFA-iLRP, FLT3-ITD, G250, hTERT, PRAME, proteinase 3, RHAMM, survivin, and WT-1 are all LAAs that have been shown to induce CD8+ T-cell recognition and for some antigens also humoral immune responses. Interestingly, most of these LAAs are linked to cell cycle or proliferation. This article discusses the balance between LAA-driven leukemia cell expansion and the elimination of these cells through attacks on LAAs by the immune system. Current knowledge of the function and CD8+ T-cell recognition of LAAs is reviewed and an outlook is given on how to improve T-cell responses to LAAs in acute myeloid leukemia cells.
    Citation
    Greiner, J., Bullinger, L., Guinn, B.A., Döhner, H., Schmitt, M. (2008) 'Leukemia-associated antigens are critical for the proliferation of acute myeloid leukemia cells' Clinical cancer research 14 (22):7161-6
    Publisher
    HighWire Press
    Journal
    Clinical cancer research : an official journal of the American Association for Cancer Research
    URI
    http://hdl.handle.net/10547/224578
    DOI
    10.1158/1078-0432.CCR-08-1102
    PubMed ID
    19010831
    Additional Links
    http://clincancerres.aacrjournals.org/content/14/22/7161.long
    Type
    Article
    Language
    en
    ISSN
    1078-0432
    ae974a485f413a2113503eed53cd6c53
    10.1158/1078-0432.CCR-08-1102
    Scopus Count
    Collections
    Biomedicine and Nutrition Research Group

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