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    Immunotherapy of acute myeloid leukaemia: development of a whole cell vaccine.

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    Authors
    Cheuk, Adam T.C.
    Guinn, Barbara-Ann
    Affiliation
    King's College London School of Medicine
    Issue Date
    2008
    Subjects
    immunotherapy
    acute myeloid leukaemia
    whole cell vaccine
    
    Metadata
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    Abstract
    Acute myeloid leukaemia (AML) is a difficult to treat disease and strategies, such as immunotherapy, which have the potential to eliminate residual tumour cells at first remission are required to reduce the incidence of relapse with its high associated mortality rates. T cells play an important role in tumor immunity and two signals are traditionally thought to be required to activate naive T cells; signal one through the major histocompatibility:antigen:T-cell receptor complex and signal two through costimulation. Many tumor associated antigens have been identified in AML suggesting it may be possible to target the immune system of AML patients; however AML develops due to tumour and immune editing, two systems by which AML cells can escape immune surveillance. By genetically modifying AML cells to express costimulatory molecules and/or cytokines, it has been possible to transform AML cells into antigen presenting cells and this has the potential to re-activate the immune system in patients. Here we summarize the rationale for using a whole cell vaccine approach to treat AML, and discuss current progress in the field of whole cell vaccine development against AML.
    Citation
    Cheuk, A. & Guinn, B. (2008) 'Immunotherapy of acute myeloid leukaemia: development of a whole cell vaccine', Frontiers in Bioscience: a journal and virtual library, 13, pp.2022-2029.
    Publisher
    bioscience.org
    Journal
    Frontiers in Bioscience : a journal and virtual library
    URI
    http://hdl.handle.net/10547/224573
    PubMed ID
    17981688
    Additional Links
    http://www.bioscience.org/2008/v13/af/2820/fulltext.htm
    Type
    Article
    Language
    en
    ISSN
    1093-4715
    Sponsors
    leukaemia and lymphoma research
    Collections
    Biomedicine and Nutrition Research Group

    entitlement

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