Androgens affect myogenesis in vitro and increase local IGF-1 expression
Authors
Sculthorpe, NicholasSolomon, Andrew M.
Sinanan, Andrea C.M.
Bouloux, Pierre-Marc G.
Grace, Fergal
Lewis, Mark P.
Affiliation
University of BedfordshireIssue Date
2012-04
Metadata
Show full item recordAbstract
The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.Citation
Sculthorpe, N., Solomon, A.M., Sinanan, A.C., Bouloux, P.M., Grace, F., and Lewis, M.P. (2012) 'Androgens affect myogenesis in vitro and increase local IGF-1 expression', Medicine and Science in Sports and Exercise, 44(4) pp.610-5.PubMed ID
21946153Type
ArticleLanguage
enISSN
1530-0315ae974a485f413a2113503eed53cd6c53
10.1249/MSS.0b013e318237c5c0
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