Androgens affect myogenesis in vitro and increase local IGF-1 expression
Solomon, Andrew M.
Sinanan, Andrea C.M.
Bouloux, Pierre-Marc G.
Lewis, Mark P.
AffiliationUniversity of Bedfordshire
MetadataShow full item record
AbstractThe mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.
CitationSculthorpe, N., Solomon, A.M., Sinanan, A.C., Bouloux, P.M., Grace, F., and Lewis, M.P. (2012) 'Androgens affect myogenesis in vitro and increase local IGF-1 expression', Medicine and Science in Sports and Exercise, 44(4) pp.610-5.