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    Androgens affect myogenesis in vitro and increase local IGF-1 expression

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    Authors
    Sculthorpe, Nicholas
    Solomon, Andrew M.
    Sinanan, Andrea C.M.
    Bouloux, Pierre-Marc G.
    Grace, Fergal
    Lewis, Mark P.
    Affiliation
    University of Bedfordshire
    Issue Date
    2012-04
    Subjects
    Androgenic Anabolic Steroids
    C760 Biomolecular Science
    
    Metadata
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    Abstract
    The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.
    Citation
    Sculthorpe, N., Solomon, A.M., Sinanan, A.C., Bouloux, P.M., Grace, F., and Lewis, M.P. (2012) 'Androgens affect myogenesis in vitro and increase local IGF-1 expression', Medicine and Science in Sports and Exercise, 44(4) pp.610-5.
    Journal
    Medicine and science in sports and exercise
    URI
    http://hdl.handle.net/10547/223813
    DOI
    10.1249/MSS.0b013e318237c5c0
    PubMed ID
    21946153
    Type
    Article
    Language
    en
    ISSN
    1530-0315
    ae974a485f413a2113503eed53cd6c53
    10.1249/MSS.0b013e318237c5c0
    Scopus Count
    Collections
    Muscle Cellular and Molecular Physiology

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