Androgens affect myogenesis in vitro and increase local IGF-1 expression
Authors
Sculthorpe, NicholasSolomon, Andrew M.
Sinanan, Andrea C.M.
Bouloux, Pierre-Marc G.
Grace, Fergal
Lewis, Mark P.
Affiliation
University of BedfordshireIssue Date
2012-04
Metadata
Show full item recordAbstract
The mechanism whereby anabolic androgens are associated with hypertrophy of skeletal muscle is incompletely understood but may involve an interaction with locally generated insulin-like growth factor (IGF) 1. The present investigation utilized a cell culture model of human skeletal muscle-derived cell maturation to test the hypothesis that androgens increase differentiation of human muscle precursor cells in vitro and to assess effects of androgen with or without IGF-1 on IGF-1 messenger RNA (mRNA) expression in human muscle precursor cells.Citation
Sculthorpe, N., Solomon, A.M., Sinanan, A.C., Bouloux, P.M., Grace, F., and Lewis, M.P. (2012) 'Androgens affect myogenesis in vitro and increase local IGF-1 expression', Medicine and Science in Sports and Exercise, 44(4) pp.610-5.PubMed ID
21946153Type
ArticleLanguage
enISSN
1530-0315ae974a485f413a2113503eed53cd6c53
10.1249/MSS.0b013e318237c5c0
Scopus Count
Collections
Related articles
- Dexamethasone administration inhibits skeletal muscle expression of the androgen receptor and IGF-1--implications for steroid-induced myopathy.
- Authors: Inder WJ, Jang C, Obeyesekere VR, Alford FP
- Issue date: 2010 Jul
- IGF-I mRNA levels in bovine satellite cell cultures: effects of fusion and anabolic steroid treatment.
- Authors: Kamanga-Sollo E, Pampusch MS, Xi G, White ME, Hathaway MR, Dayton WR
- Issue date: 2004 Nov
- Effect of voluntary exercise on the expression of IGF-I and androgen receptor in three rat skeletal muscles and on serum IGF-I and testosterone levels.
- Authors: Matsakas A, Nikolaidis MG, Kokalas N, Mougios V, Diel P
- Issue date: 2004 Oct
- Developmental changes and the impact of isoflavones on mRNA expression of IGF-I receptor, EGF receptor and related growth factors in porcine skeletal muscle cell cultures.
- Authors: Kalbe C, Mau M, Rehfeldt C
- Issue date: 2008 Oct
- Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17beta-stimulated IGF-I mRNA expression in bovine satellite cell cultures.
- Authors: Kamanga-Sollo E, White ME, Chung KY, Johnson BJ, Dayton WR
- Issue date: 2008 Oct