Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.

2.50
Hdl Handle:
http://hdl.handle.net/10547/623903
Title:
Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.
Authors:
Reimann, Frank; Diakogiannaki, Eleftheria; Moss, Catherine E.; Gribble, Fiona M.
Abstract:
Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted from the upper small intestine, which plays an important physiological role in the control of glucose metabolism through its incretin action to enhance glucose-dependent insulin secretion. GIP has also been implicated in postprandial lipid homeostasis. GIP is secreted from enteroendocrine K-cells residing in the intestinal epithelium. K-cells sense a variety of components found in the gut lumen following food consumption, resulting in an increase in plasma GIP signal dependent on the nature and quantity of ingested nutrients. We review the evidence for an important role of sodium-coupled glucose uptake through SGLT1 for carbohydrate sensing, of free-fatty acid receptors FFAR1/FFAR4 and the monoacyl-glycerol sensing receptor GPR119 for lipid detection, of the calcium-sensing receptor CASR and GPR142 for protein sensing, and additional modulation by neurotransmitters such as somatostatin and galanin. These pathways have been identified through combinations of in vivo, in vitro and molecular approaches.
Affiliation:
Wellcome Trust; University of Cambridge
Citation:
Reimann F, Diakogiannaki E, Moss CE, Gribble FM (2020) 'Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.', Peptides, 125 (), pp.170206-.
Publisher:
Elsevier
Journal:
Peptides
Issue Date:
19-Nov-2020
URI:
http://hdl.handle.net/10547/623903
DOI:
10.1016/j.peptides.2019.170206
PubMed ID:
31756367
Additional Links:
https://www.sciencedirect.com/science/article/abs/pii/S0196978119301846
Type:
Article
Language:
en
ISSN:
0196-9781
EISSN:
1873-5169
Appears in Collections:
Biomedical and biological science

Full metadata record

DC FieldValue Language
dc.contributor.authorReimann, Franken
dc.contributor.authorDiakogiannaki, Eleftheriaen
dc.contributor.authorMoss, Catherine E.en
dc.contributor.authorGribble, Fiona M.en
dc.date.accessioned2020-03-24T12:31:56Z-
dc.date.available2020-03-24T12:31:56Z-
dc.date.issued2020-11-19-
dc.identifier.citationReimann F, Diakogiannaki E, Moss CE, Gribble FM (2020) 'Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.', Peptides, 125 (), pp.170206-.en
dc.identifier.issn0196-9781-
dc.identifier.pmid31756367-
dc.identifier.doi10.1016/j.peptides.2019.170206-
dc.identifier.urihttp://hdl.handle.net/10547/623903-
dc.description.abstractGlucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted from the upper small intestine, which plays an important physiological role in the control of glucose metabolism through its incretin action to enhance glucose-dependent insulin secretion. GIP has also been implicated in postprandial lipid homeostasis. GIP is secreted from enteroendocrine K-cells residing in the intestinal epithelium. K-cells sense a variety of components found in the gut lumen following food consumption, resulting in an increase in plasma GIP signal dependent on the nature and quantity of ingested nutrients. We review the evidence for an important role of sodium-coupled glucose uptake through SGLT1 for carbohydrate sensing, of free-fatty acid receptors FFAR1/FFAR4 and the monoacyl-glycerol sensing receptor GPR119 for lipid detection, of the calcium-sensing receptor CASR and GPR142 for protein sensing, and additional modulation by neurotransmitters such as somatostatin and galanin. These pathways have been identified through combinations of in vivo, in vitro and molecular approaches.en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0196978119301846en
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF-
dc.subjectGlucose-dependent insulinotropic polypeptide (GIP)en
dc.subjectsecretionen
dc.titleCellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.en
dc.typeArticleen
dc.identifier.eissn1873-5169-
dc.contributor.departmentWellcome Trusten
dc.contributor.departmentUniversity of Cambridgeen
dc.identifier.journalPeptidesen
dc.date.updated2020-03-24T12:27:47Z-
dc.description.notemissing full text but now more than 3 months post publication so not chasing for full text. In repository at Cambridge https://www.repository.cam.ac.uk/handle/1810/299097 so may be compliant there.-
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