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Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells

2.50
Hdl Handle:
http://hdl.handle.net/10547/623391
Title:
Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells
Authors:
Yánez, Diana C.; Lau, Ching-In ( 0000-0002-7597-3478 ) ; Chawda, Mira Manilal; Ross, Susan; Furmanski, Anna L. ( 0000-0001-6126-8770 ) ; Crompton, Tessa ( 0000-0002-8973-4021 )
Abstract:
Original journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.
Affiliation:
University College London; University of Bedfordshire; Universidad San Francisco de Quito
Citation:
Yánez DC, Lau CI, Chawda MM, Ross S, Furmanski AL, Crompton T. (2019) 'Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells', Journal of Allergy and Clinical Immunology, 144 (5), pp.1419-1423.
Publisher:
Journal of Allergy and Clinical Immunology
Journal:
Journal of Allergy and Clinical Immunology
Issue Date:
24-Jul-2019
URI:
http://hdl.handle.net/10547/623391
DOI:
10.1016/j.jaci.2019.07.011
PubMed ID:
31351102
PubMed Central ID:
PMC6843897
Additional Links:
https://www.jacionline.org/article/S0091-6749(19)30948-0/abstract; https://www.sciencedirect.com/science/article/pii/S0091674919309480; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843897/
Type:
Article
Language:
en
ISSN:
0091-6749
Sponsors:
MRC, Wellcome, Asthma UK, SENESCYT, GOS NIHR BRC, Pfizer
Appears in Collections:
Biomedical and biological science

Full metadata record

DC FieldValue Language
dc.contributor.authorYánez, Diana C.en
dc.contributor.authorLau, Ching-Inen
dc.contributor.authorChawda, Mira Manilalen
dc.contributor.authorRoss, Susanen
dc.contributor.authorFurmanski, Anna L.en
dc.contributor.authorCrompton, Tessaen
dc.date.accessioned2019-08-22T13:31:59Z-
dc.date.available2019-08-22T13:31:59Z-
dc.date.issued2019-07-24-
dc.identifier.citationYánez DC, Lau CI, Chawda MM, Ross S, Furmanski AL, Crompton T. (2019) 'Hedgehog signalling promotes Th2-differentiation in naive human CD4 T-cells', Journal of Allergy and Clinical Immunology, 144 (5), pp.1419-1423.en
dc.identifier.issn0091-6749-
dc.identifier.pmid31351102-
dc.identifier.doi10.1016/j.jaci.2019.07.011-
dc.identifier.urihttp://hdl.handle.net/10547/623391-
dc.description.abstractOriginal journal article Abstract: Here we show that differentiation of human naïve CD4 T-cells to Th2 is promoted by Hedgehog signaling and attenuated by SMO-inhibition. As Hedgehog proteins are produced by epithelial tissues this finding is important to understanding atopic disease.en
dc.description.sponsorshipMRC, Wellcome, Asthma UK, SENESCYT, GOS NIHR BRC, Pfizeren
dc.language.isoenen
dc.publisherJournal of Allergy and Clinical Immunologyen
dc.relation.urlhttps://www.jacionline.org/article/S0091-6749(19)30948-0/abstracten
dc.relation.urlhttps://www.sciencedirect.com/science/article/pii/S0091674919309480en
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843897/-
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectimmunologyen
dc.subjectimmune responseen
dc.subjecthedgehog proteinsen
dc.subjectC550 Immunologyen
dc.titleHedgehog signalling promotes Th2-differentiation in naive human CD4 T-cellsen
dc.typeArticleen
dc.contributor.departmentUniversity College Londonen
dc.contributor.departmentUniversity of Bedfordshireen
dc.contributor.departmentUniversidad San Francisco de Quitoen
dc.identifier.journalJournal of Allergy and Clinical Immunologyen
dc.identifier.pmcidPMC6843897-
dc.date.updated2019-08-22T13:25:07Z-
dc.description.noteopen access article-
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