IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation

2.50
Hdl Handle:
http://hdl.handle.net/10547/623197
Title:
IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation
Authors:
Yánez, Diana C.; Sahni, Hemant; Ross, Susan; Solanki, Anisha; Lau, Ching-In; Papaioannou, Eleftheria; Barbarulo, Alessandro; Powell, Rebecca; Lange, Ulrike C.; Adams, David J.; Barenco, Martino; Ono, Masahiro; D'Acquisto, Fulvio; Furmanski, Anna L.; Crompton, Tessa ( 0000-0002-8973-4021 )
Abstract:
T cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.
Citation:
Yánez DC, Sahni H, Ross S, Solanki A, Lau CI, Papaioannou E, Barbarulo A, Powell R, Lange UC, Adams DJ, Barenco M, Ono M, D'Acquisto F, Furmanski AL, Crompton T (2019) 'IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation', European Journal of Immunology, 49 (1), pp.66-78.
Publisher:
Wiley
Journal:
European Journal of Immunology
Issue Date:
26-Oct-2018
URI:
http://hdl.handle.net/10547/623197
DOI:
10.1002/eji.201847692
PubMed ID:
30365177
Additional Links:
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.201847692
Type:
Article
Language:
en
ISSN:
0014-2980
EISSN:
0014-2980
Appears in Collections:
Health

Full metadata record

DC FieldValue Language
dc.contributor.authorYánez, Diana C.en
dc.contributor.authorSahni, Hemanten
dc.contributor.authorRoss, Susanen
dc.contributor.authorSolanki, Anishaen
dc.contributor.authorLau, Ching-Inen
dc.contributor.authorPapaioannou, Eleftheriaen
dc.contributor.authorBarbarulo, Alessandroen
dc.contributor.authorPowell, Rebeccaen
dc.contributor.authorLange, Ulrike C.en
dc.contributor.authorAdams, David J.en
dc.contributor.authorBarenco, Martinoen
dc.contributor.authorOno, Masahiroen
dc.contributor.authorD'Acquisto, Fulvioen
dc.contributor.authorFurmanski, Anna L.en
dc.contributor.authorCrompton, Tessaen
dc.date.accessioned2019-03-01T10:27:25Z-
dc.date.available2019-03-01T10:27:25Z-
dc.date.issued2018-10-26-
dc.identifier.citationYánez DC, Sahni H, Ross S, Solanki A, Lau CI, Papaioannou E, Barbarulo A, Powell R, Lange UC, Adams DJ, Barenco M, Ono M, D'Acquisto F, Furmanski AL, Crompton T (2019) 'IFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammation', European Journal of Immunology, 49 (1), pp.66-78.en
dc.identifier.issn0014-2980-
dc.identifier.pmid30365177-
dc.identifier.doi10.1002/eji.201847692-
dc.identifier.urihttp://hdl.handle.net/10547/623197-
dc.description.abstractT cells differentiated more efficiently to Th1, whereas Th2 differentiation was inhibited. Ifitm-family-deficient mice, but not Ifitm3-deficient mice, were less susceptible than WT to induction of allergic airways disease, with a weaker Th2 response and less severe disease and lower Il4 but higher Ifng expression and IL-27 secretion. Thus, the Ifitm family is important in adaptive immunity, influencing Th1/Th2 polarization, and Th2 immunopathology.en
dc.language.isoenen
dc.publisherWileyen
dc.relation.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/eji.201847692en
dc.rightsYellow - can archive pre-print (ie pre-refereeing)-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectIFITM proteinsen
dc.subjectT helper cellen
dc.subjectC550 Immunologyen
dc.titleIFITM proteins drive type 2 T helper cell differentiation and exacerbate allergic airway inflammationen
dc.typeArticleen
dc.identifier.eissn0014-2980-
dc.identifier.journalEuropean Journal of Immunologyen
dc.date.updated2019-03-01T10:24:49Z-
dc.description.noteopen access article-

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