Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease : retrospective medical record review study and a nested case -control design

2.50
Hdl Handle:
http://hdl.handle.net/10547/622710
Title:
Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease : retrospective medical record review study and a nested case -control design
Authors:
Bature, Fidelia; Pang, Dong; Robinson, Anthea; Polson, Norma; Pappas, Yannis ( 0000-0003-3087-860X ) ; Guinn, Barbara-Ann ( 0000-0003-0639-4541 )
Abstract:
OBJECTIVE: Evidence suggests that individuals with Alzheimer's disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study aimed to identify patterns in signs and symptoms preceding the clinical diagnosis of AD to suggest a predictive model for earlier diagnosis of the disease in the primary care. DESIGN: A retrospective medical record review; nested case control design. PARTICIPANTS: Participants included one hundred and nine patients from three general practice (GP) surgeries in Milton Keynes and Luton Clinical Commissioning groups (CCG) (37 cases with AD and 72 controls without AD). MAIN OUTCOME MEASURE: A retrospective analysis using the logistic regression of the presence of signs and symptoms before the diagnosis of AD was attained. Identification of the timing and sequence of appearance of these presentations as first reported before the clinical diagnosis was measured. RESULT: Episodic memory with an odds ratio of 1.85 was the most frequent presentation, documented in 1.38% of the controls and 75.6% in cases. Auditory disturbance with an odds ratio of 3.03, which has not previously been noted except in the form of auditory hallucination, could have a diagnostic value. CONCLUSION: Auditory disturbance, which occurred mostly in the Caucasian females, could discriminate individuals with AD from those without. The symptom, which presented up to 14.5 (mean time) years prior to clinical diagnosis, was identified in Caucasians and mixed race individuals only.
Citation:
Bature F, Pang D, Robinson A, Polson N, Pappas Y, Guinn B. (2018) 'Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease : retrospective medical record review study and a nested case -control design', Current Alzheimer Research, (), pp.-.
Publisher:
Bentham
Journal:
Current Alzheimer Research
Issue Date:
4-Apr-2018
URI:
http://hdl.handle.net/10547/622710
DOI:
10.2174/1567205015666180404155358
PubMed ID:
29623839
Additional Links:
http://www.eurekaselect.com/160998/article
Type:
Article
Language:
en
ISSN:
1567-2050
Appears in Collections:
Health

Full metadata record

DC FieldValue Language
dc.contributor.authorBature, Fideliaen
dc.contributor.authorPang, Dongen
dc.contributor.authorRobinson, Antheaen
dc.contributor.authorPolson, Normaen
dc.contributor.authorPappas, Yannisen
dc.contributor.authorGuinn, Barbara-Annen
dc.date.accessioned2018-05-14T09:12:20Z-
dc.date.available2018-05-14T09:12:20Z-
dc.date.issued2018-04-04-
dc.identifier.citationBature F, Pang D, Robinson A, Polson N, Pappas Y, Guinn B. (2018) 'Identifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease : retrospective medical record review study and a nested case -control design', Current Alzheimer Research, (), pp.-.en
dc.identifier.issn1567-2050-
dc.identifier.pmid29623839-
dc.identifier.doi10.2174/1567205015666180404155358-
dc.identifier.urihttp://hdl.handle.net/10547/622710-
dc.description.abstractOBJECTIVE: Evidence suggests that individuals with Alzheimer's disease (AD) are often diagnosed in the later stages of their disease with a poor prognosis. This study aimed to identify patterns in signs and symptoms preceding the clinical diagnosis of AD to suggest a predictive model for earlier diagnosis of the disease in the primary care. DESIGN: A retrospective medical record review; nested case control design. PARTICIPANTS: Participants included one hundred and nine patients from three general practice (GP) surgeries in Milton Keynes and Luton Clinical Commissioning groups (CCG) (37 cases with AD and 72 controls without AD). MAIN OUTCOME MEASURE: A retrospective analysis using the logistic regression of the presence of signs and symptoms before the diagnosis of AD was attained. Identification of the timing and sequence of appearance of these presentations as first reported before the clinical diagnosis was measured. RESULT: Episodic memory with an odds ratio of 1.85 was the most frequent presentation, documented in 1.38% of the controls and 75.6% in cases. Auditory disturbance with an odds ratio of 3.03, which has not previously been noted except in the form of auditory hallucination, could have a diagnostic value. CONCLUSION: Auditory disturbance, which occurred mostly in the Caucasian females, could discriminate individuals with AD from those without. The symptom, which presented up to 14.5 (mean time) years prior to clinical diagnosis, was identified in Caucasians and mixed race individuals only.en
dc.language.isoenen
dc.publisherBenthamen
dc.relation.urlhttp://www.eurekaselect.com/160998/articleen
dc.rightsYellow - can archive pre-print (ie pre-refereeing)-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectB140 Neuroscienceen
dc.subjectAlzheimer's diseaseen
dc.titleIdentifying patterns in signs and symptoms preceding the clinical diagnosis of Alzheimer's disease : retrospective medical record review study and a nested case -control designen
dc.typeArticleen
dc.identifier.journalCurrent Alzheimer Researchen
dc.date.updated2018-05-14T09:07:22Z-

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