Maternal and perinatal risk factors for childhood cancer: record linkage study

2.50
Hdl Handle:
http://hdl.handle.net/10547/622588
Title:
Maternal and perinatal risk factors for childhood cancer: record linkage study
Authors:
Bhattacharya, Sohinee; Beasley, Marcus; Pang, Dong; Macfarlane, Gary J.
Abstract:
Objective To investigate maternal and perinatal risk factors for childhood cancer. Study design Case–control analysis of linked records from the Aberdeen Maternity and Neonatal Databank with the Scottish Cancer Registry and the General Registry of Births and Deaths in Scotland was carried out. Setting Aberdeen, Scotland. Participants Cases (n=176) comprised children diagnosed with cancer under 15 years or recorded as having died of cancer. Four controls per case were matched by age and gender. Risk factors tested Maternal age, body mass index, social class, marital status and smoking as well as pre-eclampsia, antepartum haemorrhage and previous miscarriage, gestational age, birth weight and Apgar scores were compared between groups to test for association with cancer. ORs with 95% CIs were calculated using conditional logistic regression in univariable and multivariable models. Results Of the maternal characteristics tested, mother's age at delivery (cases mean 28.9 (SD 5.6) years vs controls mean 30.2 (SD 4.6), p=0.002) and smoking status (38.6% smokers among cases, 29.7% among controls, p=0.034) were found to be different between groups. Of the perinatal factors tested, low Apgar score at 5 min (adjusted OR (AOR) 4.59, 95% CI 1.52 to 13.87) and delivery by caesarean section (AOR 1.95, 95% CI 1.30 to 2.92) showed statistically significant associations with childhood cancer in the multivariable model. Conclusions Younger maternal age, maternal smoking, delivery by caesarean section and low Apgar score at 5 min were independently associated with increased risk of childhood cancer. These general findings should be interpreted with caution as this study did not have the power to detect any association with individual diagnostic categories of childhood cancer. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
Affiliation:
University of Aberdeen; University of Bedfordshire
Citation:
Bhattacharya S, Beasley M, Pang D, Macfarlane GR (2014) 'Maternal and perinatal risk factors for childhood cancer: record linkage study', BMJ Open, 4 (1), pp.-.
Publisher:
BMJ
Journal:
BMJ Open
Issue Date:
6-Jan-2014
URI:
http://hdl.handle.net/10547/622588
DOI:
10.1136/bmjopen-2013-003656
Additional Links:
http://bmjopen.bmj.com/content/4/1/e003656
Type:
Article
Language:
en
ISSN:
2044-6055
Appears in Collections:
Health

Full metadata record

DC FieldValue Language
dc.contributor.authorBhattacharya, Sohineeen
dc.contributor.authorBeasley, Marcusen
dc.contributor.authorPang, Dongen
dc.contributor.authorMacfarlane, Gary J.en
dc.date.accessioned2018-04-04T14:08:23Z-
dc.date.available2018-04-04T14:08:23Z-
dc.date.issued2014-01-06-
dc.identifier.citationBhattacharya S, Beasley M, Pang D, Macfarlane GR (2014) 'Maternal and perinatal risk factors for childhood cancer: record linkage study', BMJ Open, 4 (1), pp.-.en
dc.identifier.issn2044-6055-
dc.identifier.doi10.1136/bmjopen-2013-003656-
dc.identifier.urihttp://hdl.handle.net/10547/622588-
dc.description.abstractObjective To investigate maternal and perinatal risk factors for childhood cancer. Study design Case–control analysis of linked records from the Aberdeen Maternity and Neonatal Databank with the Scottish Cancer Registry and the General Registry of Births and Deaths in Scotland was carried out. Setting Aberdeen, Scotland. Participants Cases (n=176) comprised children diagnosed with cancer under 15 years or recorded as having died of cancer. Four controls per case were matched by age and gender. Risk factors tested Maternal age, body mass index, social class, marital status and smoking as well as pre-eclampsia, antepartum haemorrhage and previous miscarriage, gestational age, birth weight and Apgar scores were compared between groups to test for association with cancer. ORs with 95% CIs were calculated using conditional logistic regression in univariable and multivariable models. Results Of the maternal characteristics tested, mother's age at delivery (cases mean 28.9 (SD 5.6) years vs controls mean 30.2 (SD 4.6), p=0.002) and smoking status (38.6% smokers among cases, 29.7% among controls, p=0.034) were found to be different between groups. Of the perinatal factors tested, low Apgar score at 5 min (adjusted OR (AOR) 4.59, 95% CI 1.52 to 13.87) and delivery by caesarean section (AOR 1.95, 95% CI 1.30 to 2.92) showed statistically significant associations with childhood cancer in the multivariable model. Conclusions Younger maternal age, maternal smoking, delivery by caesarean section and low Apgar score at 5 min were independently associated with increased risk of childhood cancer. These general findings should be interpreted with caution as this study did not have the power to detect any association with individual diagnostic categories of childhood cancer. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/en
dc.language.isoenen
dc.publisherBMJen
dc.relation.urlhttp://bmjopen.bmj.com/content/4/1/e003656en
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectepidemiologyen
dc.subjectchildhood canceren
dc.titleMaternal and perinatal risk factors for childhood cancer: record linkage studyen
dc.typeArticleen
dc.contributor.departmentUniversity of Aberdeenen
dc.contributor.departmentUniversity of Bedfordshireen
dc.identifier.journalBMJ Openen
dc.date.updated2018-04-04T13:20:14Z-
dc.description.noteopen access-
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