Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase

2.50
Hdl Handle:
http://hdl.handle.net/10547/622564
Title:
Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase
Authors:
Jadoon, Ayesha; Cunningham, Phil; McDermott, Lindsay C.
Abstract:
Arachidonic acid (ARA) metabolites maintain pregnancy and control parturition.We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.
Citation:
Jadoon A, Cunningham P, McDermott LC (2014) 'Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase', Placenta, 35 (6), pp.422-424.
Publisher:
Elsevier
Journal:
Placenta
Issue Date:
8-Apr-2014
URI:
http://hdl.handle.net/10547/622564
DOI:
10.1016/j.placenta.2014.03.024
Additional Links:
http://www.placentajournal.org/article/S0143-4004(14)00133-7/fulltext
Type:
Article
Language:
en
ISSN:
0143-4004
Sponsors:
EPSRC DTA award EP/P504961/1
Appears in Collections:
Biomedical and biological science

Full metadata record

DC FieldValue Language
dc.contributor.authorJadoon, Ayeshaen
dc.contributor.authorCunningham, Philen
dc.contributor.authorMcDermott, Lindsay C.en
dc.date.accessioned2018-03-27T09:48:39Z-
dc.date.available2018-03-27T09:48:39Z-
dc.date.issued2014-04-08-
dc.identifier.citationJadoon A, Cunningham P, McDermott LC (2014) 'Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase', Placenta, 35 (6), pp.422-424.en
dc.identifier.issn0143-4004-
dc.identifier.doi10.1016/j.placenta.2014.03.024-
dc.identifier.urihttp://hdl.handle.net/10547/622564-
dc.description.abstractArachidonic acid (ARA) metabolites maintain pregnancy and control parturition.We generated a network of 77 proteins involved in placental ARA metabolism to identify novel proteins in this pathway. We identified a long pathway within this network which showed that secretory and cytosolic phospholipase A2 proteins act in concert. The functions of all network proteins expressed in the placental decidua were determined by database searches. Thus ARA metabolism was linked to carbohydrate metabolism. One protein, transmembrane protein 62 (TMEM62), expressed in decidua was previously uncharacterized, and was identified as a putative lipoxygenase. TMEM62 may play a role in pregnancy and/or parturition.en
dc.description.sponsorshipEPSRC DTA award EP/P504961/1en
dc.language.isoenen
dc.publisherElsevieren
dc.relation.urlhttp://www.placentajournal.org/article/S0143-4004(14)00133-7/fulltexten
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF-
dc.subjectmetabolismen
dc.subjectmathematicsen
dc.subjectcomputational imagingen
dc.subjectarachidonic aciden
dc.subjectmetabolismen
dc.subjectprotein–protein interactionsen
dc.subjectleukotrienesen
dc.subjectlipoxygenaseen
dc.titleArachidonic acid metabolism in the human placenta: identification of a putative lipoxygenaseen
dc.typeArticleen
dc.identifier.journalPlacentaen
dc.date.updated2018-03-27T09:20:50Z-
dc.description.notepre April 2016 so no file required-
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