Inhibition effects of paeonol on mice bearing EMT6 breast cancer through inducing rumor cell apoptosis

2.50
Hdl Handle:
http://hdl.handle.net/10547/622230
Title:
Inhibition effects of paeonol on mice bearing EMT6 breast cancer through inducing rumor cell apoptosis
Authors:
Song, Hanjun; Wang, Jianjie; Li, Lijiang; Wang, Molin; Dong, Hang; Luo, Wenzhe; Zhou, Shaobo ( 0000-0001-5214-2973 )
Abstract:
Paeonol, a phenolic component from the root bark of Paeonia moutan, has been identified to possess antitumor effects on mice bearing EMT6 breast cancer in our previous studies. However, the underlying mechanisms remain unknown. In the present study the molecular mechanisms of paeonol were further investigated in EMT6 mice model. The results showed that treatment of mice with 175 and 350 mg/kg/day of paeonol significantly inhibited the growth of the EMT6 tumor in mice, and induced tumor cell apoptosis which were demonstrated by light microscopy after hematoxylin and eosin staining and apoptosis analysis by flow cytometry. In addition, compared with the control group, paeonol increased the number of tumor cells in G0/G1 phase but decreased the number of cells in S and G2/M phase. Paeonol treatment (350 mg/kg body weight) also resulted in a decrease of Bcl-2 and an increase in Bax and caspase-3 expressions, which were demonstrated by immunohistochemical and western blot analysis. These results indicate that the antitumor effects of paeonol might be associated with arresting tumor cells in the G0/G1 phase, inducing cell apoptosis and regulation of the expression of Bcl-2, Bax and activation of caspase-3.
Affiliation:
Jiamusi University; University of Bedfordshire
Citation:
Song H, Wang J, Li L, Wang M, Dong H, Luo W, Zhou S (2014) 'Inhibition effects of paeonol on mice bearing EMT6 breast cancer through inducing rumor cell apoptosis', Acta Farmaceutica Bonaerense, 33 (1), pp.101-107.
Journal:
Acta Farmaceutica Bonaerense
Issue Date:
11-Nov-2014
URI:
http://hdl.handle.net/10547/622230
Additional Links:
http://www.latamjpharm.org/resumenes/33/1/LAJOP_33_1_1_13.pdf
Type:
Article
Language:
en
ISSN:
0326-2383
Appears in Collections:
Biomedical and biological science

Full metadata record

DC FieldValue Language
dc.contributor.authorSong, Hanjunen
dc.contributor.authorWang, Jianjieen
dc.contributor.authorLi, Lijiangen
dc.contributor.authorWang, Molinen
dc.contributor.authorDong, Hangen
dc.contributor.authorLuo, Wenzheen
dc.contributor.authorZhou, Shaoboen
dc.date.accessioned2017-09-25T11:38:46Z-
dc.date.available2017-09-25T11:38:46Z-
dc.date.issued2014-11-11-
dc.identifier.citationSong H, Wang J, Li L, Wang M, Dong H, Luo W, Zhou S (2014) 'Inhibition effects of paeonol on mice bearing EMT6 breast cancer through inducing rumor cell apoptosis', Acta Farmaceutica Bonaerense, 33 (1), pp.101-107.en
dc.identifier.issn0326-2383-
dc.identifier.urihttp://hdl.handle.net/10547/622230-
dc.description.abstractPaeonol, a phenolic component from the root bark of Paeonia moutan, has been identified to possess antitumor effects on mice bearing EMT6 breast cancer in our previous studies. However, the underlying mechanisms remain unknown. In the present study the molecular mechanisms of paeonol were further investigated in EMT6 mice model. The results showed that treatment of mice with 175 and 350 mg/kg/day of paeonol significantly inhibited the growth of the EMT6 tumor in mice, and induced tumor cell apoptosis which were demonstrated by light microscopy after hematoxylin and eosin staining and apoptosis analysis by flow cytometry. In addition, compared with the control group, paeonol increased the number of tumor cells in G0/G1 phase but decreased the number of cells in S and G2/M phase. Paeonol treatment (350 mg/kg body weight) also resulted in a decrease of Bcl-2 and an increase in Bax and caspase-3 expressions, which were demonstrated by immunohistochemical and western blot analysis. These results indicate that the antitumor effects of paeonol might be associated with arresting tumor cells in the G0/G1 phase, inducing cell apoptosis and regulation of the expression of Bcl-2, Bax and activation of caspase-3.en
dc.language.isoenen
dc.relation.urlhttp://www.latamjpharm.org/resumenes/33/1/LAJOP_33_1_1_13.pdfen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectpaeonolen
dc.subjectbreast canceren
dc.subjecttumorsen
dc.titleInhibition effects of paeonol on mice bearing EMT6 breast cancer through inducing rumor cell apoptosisen
dc.typeArticleen
dc.contributor.departmentJiamusi Universityen
dc.contributor.departmentUniversity of Bedfordshireen
dc.identifier.journalActa Farmaceutica Bonaerenseen
dc.date.updated2017-09-25T11:16:42Z-
dc.description.noteNo info on Sherpa Romeo and unable to find contact detals for publisher. As is available freely on website and over 3 years old am going to assume full text is OK unless publisher contacts us to say otherwise. RVO 25-9-17-
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