β-alanine supplementation improves in-vivo fresh and fatigued muscle relaxation speed

2.50
Hdl Handle:
http://hdl.handle.net/10547/622226
Title:
β-alanine supplementation improves in-vivo fresh and fatigued muscle relaxation speed
Authors:
Jones, Rebecca Louise ( 0000-0001-9657-9448 ) ; Barnett, Cleveland Thomas; Davidson, Joel; Maritza, Billy; Fraser, William D.; Harris, Roger C.; Sale, Craig ( 0000-0002-5816-4169 )
Other Titles:
β-alanine supplementation improves skeletal muscle relaxation
Abstract:
PURPOSE: In fresh muscle, supplementation with the rate-limiting precursor of carnosine, β-alanine (BA), results in a decline in muscle half-relaxation time (HRT) potentially via alterations to calcium (Ca2+) handling. Accumulation of hydrogen cation (H+) has been shown to impact Ca2+ signalling during muscular contraction, carnosine has the potential to serve as a cytoplasmic regulator of Ca2+ and H+ coupling, since it binds to both ions. The present study examined the effect of BA supplementation on intrinsic in-vivo isometric knee extensor force production and muscle contractility in both fresh and fatigued human skeletal muscle assessed during voluntary and electrically evoked (nerve and superficial muscle stimulation) contractions. METHODS: Twenty-three males completed two experimental sessions, pre- and post- 28 day supplementation with 6.4 g.day-1 of BA (n = 12) or placebo (PLA; n = 11). Isometric force was recorded during a series of voluntary and electrically evoked knee extensor contractions. RESULTS: BA supplementation had no effect on voluntary or electrically evoked isometric force production, or twitch electromechanical delay and time-to-peak tension. There was a significant decline in muscle HRT in fresh and fatigued muscle conditions during both resting (3 ± 13%; 19 ± 26%) and potentiated (1 ± 15%; 2 ± 20%) twitch contractions. CONCLUSIONS: The mechanism for reduced HRT in fresh and fatigued skeletal muscle following BA supplementation is unclear. Due to the importance of muscle relaxation on total energy consumption, especially during short, repeated contractions, BA supplementation may prove to be beneficial in minimising contractile slowing induced by fatigue. TRIAL REGISTRATION: The trial is registered with Clinicaltrials.gov, ID number NCT02819505.
Affiliation:
Nottingham Trent University; University of East Anglia; Norfolk and Norwich University Hospital; Junipa Ltd
Citation:
Jones R.L., Barnett C.T., Davidson J., Maritza B., Fraser W.D., Harris R.C., Sale C. (2017) 'β-alanine supplementation improves in-vivo fresh and fatigued muscle relaxation speed', European Journal of Applied Physiology, 117 (5), pp.867-879.
Publisher:
Springer International Publishing AG
Journal:
European Journal of Applied Physiology
Issue Date:
20-Sep-2017
URI:
http://hdl.handle.net/10547/622226
DOI:
10.1007/s00421-017-3569-1
PubMed ID:
28349262
PubMed Central ID:
PMC5388709
Additional Links:
https://link.springer.com/article/10.1007/s00421-017-3569-1
Type:
Article
Language:
en
ISSN:
1439-6319
EISSN:
1439-6327
Appears in Collections:
Sport and physical activity

Full metadata record

DC FieldValue Language
dc.contributor.authorJones, Rebecca Louiseen
dc.contributor.authorBarnett, Cleveland Thomasen
dc.contributor.authorDavidson, Joelen
dc.contributor.authorMaritza, Billyen
dc.contributor.authorFraser, William D.en
dc.contributor.authorHarris, Roger C.en
dc.contributor.authorSale, Craigen
dc.date.accessioned2017-09-22T11:26:20Z-
dc.date.available2017-09-22T11:26:20Z-
dc.date.issued2017-09-20-
dc.identifier.citationJones R.L., Barnett C.T., Davidson J., Maritza B., Fraser W.D., Harris R.C., Sale C. (2017) 'β-alanine supplementation improves in-vivo fresh and fatigued muscle relaxation speed', European Journal of Applied Physiology, 117 (5), pp.867-879.en
dc.identifier.issn1439-6319-
dc.identifier.pmid28349262-
dc.identifier.doi10.1007/s00421-017-3569-1-
dc.identifier.urihttp://hdl.handle.net/10547/622226-
dc.description.abstractPURPOSE: In fresh muscle, supplementation with the rate-limiting precursor of carnosine, β-alanine (BA), results in a decline in muscle half-relaxation time (HRT) potentially via alterations to calcium (Ca2+) handling. Accumulation of hydrogen cation (H+) has been shown to impact Ca2+ signalling during muscular contraction, carnosine has the potential to serve as a cytoplasmic regulator of Ca2+ and H+ coupling, since it binds to both ions. The present study examined the effect of BA supplementation on intrinsic in-vivo isometric knee extensor force production and muscle contractility in both fresh and fatigued human skeletal muscle assessed during voluntary and electrically evoked (nerve and superficial muscle stimulation) contractions. METHODS: Twenty-three males completed two experimental sessions, pre- and post- 28 day supplementation with 6.4 g.day-1 of BA (n = 12) or placebo (PLA; n = 11). Isometric force was recorded during a series of voluntary and electrically evoked knee extensor contractions. RESULTS: BA supplementation had no effect on voluntary or electrically evoked isometric force production, or twitch electromechanical delay and time-to-peak tension. There was a significant decline in muscle HRT in fresh and fatigued muscle conditions during both resting (3 ± 13%; 19 ± 26%) and potentiated (1 ± 15%; 2 ± 20%) twitch contractions. CONCLUSIONS: The mechanism for reduced HRT in fresh and fatigued skeletal muscle following BA supplementation is unclear. Due to the importance of muscle relaxation on total energy consumption, especially during short, repeated contractions, BA supplementation may prove to be beneficial in minimising contractile slowing induced by fatigue. TRIAL REGISTRATION: The trial is registered with Clinicaltrials.gov, ID number NCT02819505.en
dc.language.isoenen
dc.publisherSpringer International Publishing AGen
dc.relation.urlhttps://link.springer.com/article/10.1007/s00421-017-3569-1en
dc.rightsGreen - can archive pre-print and post-print or publisher's version/PDF-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectmuscleen
dc.subjectcarnosineen
dc.subjectcontractile propertiesen
dc.subjectelectrical stimulationen
dc.subjectmuscle fatigueen
dc.subjectbeta-alanineen
dc.subjectC600 Sports Scienceen
dc.titleβ-alanine supplementation improves in-vivo fresh and fatigued muscle relaxation speeden
dc.title.alternativeβ-alanine supplementation improves skeletal muscle relaxationen
dc.typeArticleen
dc.identifier.eissn1439-6327-
dc.contributor.departmentNottingham Trent Universityen
dc.contributor.departmentUniversity of East Angliaen
dc.contributor.departmentNorfolk and Norwich University Hospitalen
dc.contributor.departmentJunipa Ltden
dc.identifier.journalEuropean Journal of Applied Physiologyen
dc.identifier.pmcidPMC5388709-
dc.date.updated2017-09-22T11:03:47Z-
dc.description.noteopen access article-

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