β-alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacity

2.50
Hdl Handle:
http://hdl.handle.net/10547/622223
Title:
β-alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacity
Authors:
Hannah, Ricci ( 0000-0001-5379-3292 ) ; Jones, Rebecca Louise ( 0000-0001-9657-9448 ) ; Minshull, Claire; Artioli, Guilherme Giannini ( 0000-0001-8463-2213 ) ; Harris, Roger C.; Sale, Craig ( 0000-0002-5816-4169 )
Other Titles:
β-alanine supplementation and muscle contractile properties
Abstract:
PURPOSE: β-alanine (BA) supplementation improves human exercise performance. One possible explanation for this is an enhancement of muscle contractile properties, occurring via elevated intramuscular carnosine resulting in improved calcium sensitivity and handling. This study investigated the effect of BA supplementation on in vivo contractile properties and voluntary neuromuscular performance. METHODS: Twenty-three men completed two experimental sessions, pre- and post-28 days supplementation with 6.4 g·d-1 39 of BA (n = 12) or placebo (PLA; n = 11). During each session, force was recorded during a series of knee extensor contractions: resting and potentiated twitches and octet (8 pulses, 300 Hz) contractions elicited via femoral nerve stimulation; tetanic contractions (1 s, 1 – 100 Hz) via superficial muscle stimulation; and maximum and explosive voluntary contractions. RESULTS: BA supplementation had no effect on the force-frequency relationship, or the force responses (force at 25 ms and 50 ms from onset, peak force) of resting or potentiated twitches, and octet contractions (P > 0.05). Resting and potentiated twitch electromechanical delay and time-to-peak tension were unaffected by BA supplementation (P > 0.05), although half-relaxation time declined by 7-12% (P < 0.05). Maximum and explosive voluntary forces were unchanged after BA supplementation. CONCLUSION: BA supplementation had no effect on evoked force responses, implying that altered calcium sensitivity and/or release are not the mechanisms by which BA supplementation influences exercise performance. The reduced half-relaxation time with BA supplementation might, however, be explained by enhanced reuptake of calcium, which has implications for the efficiency of muscle contraction following BA supplementation.
Citation:
Hannah R., Stannard R.L., Minshull C., Artioli G.G., Harris R.C, Sale C (2015) 'β-alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacity', Journal of Applied Physiology, 118 (5), pp.604-612.
Publisher:
American Physiological Society
Journal:
Journal of Applied Physiology
Issue Date:
1-Mar-2015
URI:
http://hdl.handle.net/10547/622223
DOI:
10.1152/japplphysiol.00991.2014
Additional Links:
http://jap.physiology.org/content/118/5/604
Type:
Article
Language:
en
ISSN:
8750-7587
EISSN:
1522-1601
Appears in Collections:
Sport and physical activity

Full metadata record

DC FieldValue Language
dc.contributor.authorHannah, Riccien
dc.contributor.authorJones, Rebecca Louiseen
dc.contributor.authorMinshull, Claireen
dc.contributor.authorArtioli, Guilherme Gianninien
dc.contributor.authorHarris, Roger C.en
dc.contributor.authorSale, Craigen
dc.date.accessioned2017-09-22T11:26:00Z-
dc.date.available2017-09-22T11:26:00Z-
dc.date.issued2015-03-01-
dc.identifier.citationHannah R., Stannard R.L., Minshull C., Artioli G.G., Harris R.C, Sale C (2015) 'β-alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacity', Journal of Applied Physiology, 118 (5), pp.604-612.en
dc.identifier.issn8750-7587-
dc.identifier.doi10.1152/japplphysiol.00991.2014-
dc.identifier.urihttp://hdl.handle.net/10547/622223-
dc.description.abstractPURPOSE: β-alanine (BA) supplementation improves human exercise performance. One possible explanation for this is an enhancement of muscle contractile properties, occurring via elevated intramuscular carnosine resulting in improved calcium sensitivity and handling. This study investigated the effect of BA supplementation on in vivo contractile properties and voluntary neuromuscular performance. METHODS: Twenty-three men completed two experimental sessions, pre- and post-28 days supplementation with 6.4 g·d-1 39 of BA (n = 12) or placebo (PLA; n = 11). During each session, force was recorded during a series of knee extensor contractions: resting and potentiated twitches and octet (8 pulses, 300 Hz) contractions elicited via femoral nerve stimulation; tetanic contractions (1 s, 1 – 100 Hz) via superficial muscle stimulation; and maximum and explosive voluntary contractions. RESULTS: BA supplementation had no effect on the force-frequency relationship, or the force responses (force at 25 ms and 50 ms from onset, peak force) of resting or potentiated twitches, and octet contractions (P > 0.05). Resting and potentiated twitch electromechanical delay and time-to-peak tension were unaffected by BA supplementation (P > 0.05), although half-relaxation time declined by 7-12% (P < 0.05). Maximum and explosive voluntary forces were unchanged after BA supplementation. CONCLUSION: BA supplementation had no effect on evoked force responses, implying that altered calcium sensitivity and/or release are not the mechanisms by which BA supplementation influences exercise performance. The reduced half-relaxation time with BA supplementation might, however, be explained by enhanced reuptake of calcium, which has implications for the efficiency of muscle contraction following BA supplementation.en
dc.language.isoenen
dc.publisherAmerican Physiological Societyen
dc.relation.urlhttp://jap.physiology.org/content/118/5/604en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectbeta-alanineen
dc.subjectmuscle contractile propertiesen
dc.subjectelectrical stimulationen
dc.subjectforce-frequency relationshipen
dc.subjectC600 Sports Scienceen
dc.titleβ-alanine supplementation enhances human skeletal muscle relaxation speed but not force production capacityen
dc.title.alternativeβ-alanine supplementation and muscle contractile propertiesen
dc.typeArticleen
dc.identifier.eissn1522-1601-
dc.identifier.journalJournal of Applied Physiologyen
dc.date.updated2017-09-22T11:03:50Z-
This item is licensed under a Creative Commons License
Creative Commons
All Items in UOBREP are protected by copyright, with all rights reserved, unless otherwise indicated.