The dose-response to sodium bicarbonate ingestion highlights the need for individuality in supplementation
Authors
Jones, Rebecca LouiseStellingwerff, Trent
Artioli, Guilherme Giannini
Saunders, Bryan
Cooper, Simon
Sale, Craig
Issue Date
2016-10-01
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To defend against hydrogen cation accumulation and muscle fatigue during exercise, sodium bicarbonate (NaHCO3) ingestion is commonplace. The individualized dose-response relationship between NaHCO3 ingestion and blood biochemistry is unclear. The present study investigated the bicarbonate, pH, base excess and sodium responses to NaHCO3 ingestion. Sixteen healthy males (23 ± 2 years; 78.6 ± 15.1 kg) attended three randomized order-balanced, nonblinded sessions, ingesting a single dose of either 0.1, 0.2 or 0.3 g·kg-1BM of NaHCO3 (Intralabs, UK). Fingertip capillary blood was obtained at baseline and every 10 min for 1 hr, then every 15 min for a further 2 hr. There was a significant main effect of both time and condition for all assessed blood analytes (p ≤ .001). Blood analyte responses were significantly lower following 0.1 g·kg-1BM compared with 0.2 g·kg-1BM; bicarbonate concentrations and base excess were highest following ingestion of 0.3 g·kg-1BM (p ≤ .01). Bicarbonate concentrations and pH significantly increased from baseline following all doses; the higher the dose the greater the increase. Large interindividual variability was shown in the magnitude of the increase in bicarbonate concentrations following each dose (+2.0-5; +5.1-8.1; and +6.0-12.3 mmol·L-1 for 0.1, 0.2 and 0.3 g·kg-1BM) and in the range of time to peak concentrations (30-150; 40-165; and 75-180 min for 0.1, 0.2 and 0.3 g·kg-1BM). The variability in bicarbonate responses was not affected by normalization to body mass. These results challenge current practices relating to NaHCO3 supplementation and clearly show the need for athletes to individualize their ingestion protocol and trial varying dosages before competition.Citation
Jones RL, Stellingwerff T, Artioli GG, Saunders B, Cooper S, Sale C. (2016) 'The dose-response to sodium bicarbonate ingestion highlights the need for individuality in supplementation', International Journal of Sport Nutrition and Exercise Metabolism, 26 (5), pp.445-453.Publisher
Human Kinetics JournalPubMed ID
27098290Additional Links
https://www.ncbi.nlm.nih.gov/pubmed/27098290http://journals.humankinetics.com/doi/abs/10.1123/ijsnem.2015-0286
Type
ArticleLanguage
enISSN
1526-484XEISSN
1543-2742ae974a485f413a2113503eed53cd6c53
10.1123/ijsnem.2015-0286
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