The dose-response to sodium bicarbonate ingestion highlights the need for individuality in supplementation

2.50
Hdl Handle:
http://hdl.handle.net/10547/622199
Title:
The dose-response to sodium bicarbonate ingestion highlights the need for individuality in supplementation
Authors:
Jones, Rebecca Louise ( 0000-0001-9657-9448 ) ; Stellingwerff, Trent; Artioli, Guilherme Giannini ( 0000-0001-8463-2213 ) ; Saunders, Bryan ( 0000-0003-0995-9077 ) ; Cooper, Simon; Sale, Craig ( 0000-0002-5816-4169 )
Abstract:
To defend against hydrogen cation accumulation and muscle fatigue during exercise, sodium bicarbonate (NaHCO3) ingestion is commonplace. The individualized dose-response relationship between NaHCO3 ingestion and blood biochemistry is unclear. The present study investigated the bicarbonate, pH, base excess and sodium responses to NaHCO3 ingestion. Sixteen healthy males (23 ± 2 years; 78.6 ± 15.1 kg) attended three randomized order-balanced, nonblinded sessions, ingesting a single dose of either 0.1, 0.2 or 0.3 g·kg-1BM of NaHCO3 (Intralabs, UK). Fingertip capillary blood was obtained at baseline and every 10 min for 1 hr, then every 15 min for a further 2 hr. There was a significant main effect of both time and condition for all assessed blood analytes (p ≤ .001). Blood analyte responses were significantly lower following 0.1 g·kg-1BM compared with 0.2 g·kg-1BM; bicarbonate concentrations and base excess were highest following ingestion of 0.3 g·kg-1BM (p ≤ .01). Bicarbonate concentrations and pH significantly increased from baseline following all doses; the higher the dose the greater the increase. Large interindividual variability was shown in the magnitude of the increase in bicarbonate concentrations following each dose (+2.0-5; +5.1-8.1; and +6.0-12.3 mmol·L-1 for 0.1, 0.2 and 0.3 g·kg-1BM) and in the range of time to peak concentrations (30-150; 40-165; and 75-180 min for 0.1, 0.2 and 0.3 g·kg-1BM). The variability in bicarbonate responses was not affected by normalization to body mass. These results challenge current practices relating to NaHCO3 supplementation and clearly show the need for athletes to individualize their ingestion protocol and trial varying dosages before competition.
Affiliation:
Nottingham Trent University; Canadian Sport Institute; University of São Paulo
Citation:
Jones RL, Stellingwerff T, Artioli GG, Saunders B, Cooper S, Sale C. (2016) 'The dose-response to sodium bicarbonate ingestion highlights the need for individuality in supplementation', International Journal of Sport Nutrition and Exercise Metabolism, 26 (5), pp.445-453.
Publisher:
Human Kinetics Journal
Journal:
International Journal of Sport Nutrition and Exercise Metabolism
Issue Date:
1-Oct-2016
URI:
http://hdl.handle.net/10547/622199
DOI:
10.1123/ijsnem.2015-0286
PubMed ID:
27098290
Additional Links:
https://www.ncbi.nlm.nih.gov/pubmed/27098290; http://journals.humankinetics.com/doi/abs/10.1123/ijsnem.2015-0286
Type:
Article
Language:
en
ISSN:
1526-484X
EISSN:
1543-2742
Appears in Collections:
Sport and physical activity

Full metadata record

DC FieldValue Language
dc.contributor.authorJones, Rebecca Louiseen
dc.contributor.authorStellingwerff, Trenten
dc.contributor.authorArtioli, Guilherme Gianninien
dc.contributor.authorSaunders, Bryanen
dc.contributor.authorCooper, Simonen
dc.contributor.authorSale, Craigen
dc.date.accessioned2017-09-21T12:57:37Z-
dc.date.available2017-09-21T12:57:37Z-
dc.date.issued2016-10-01-
dc.identifier.citationJones RL, Stellingwerff T, Artioli GG, Saunders B, Cooper S, Sale C. (2016) 'The dose-response to sodium bicarbonate ingestion highlights the need for individuality in supplementation', International Journal of Sport Nutrition and Exercise Metabolism, 26 (5), pp.445-453.en
dc.identifier.issn1526-484X-
dc.identifier.pmid27098290-
dc.identifier.doi10.1123/ijsnem.2015-0286-
dc.identifier.urihttp://hdl.handle.net/10547/622199-
dc.description.abstractTo defend against hydrogen cation accumulation and muscle fatigue during exercise, sodium bicarbonate (NaHCO3) ingestion is commonplace. The individualized dose-response relationship between NaHCO3 ingestion and blood biochemistry is unclear. The present study investigated the bicarbonate, pH, base excess and sodium responses to NaHCO3 ingestion. Sixteen healthy males (23 ± 2 years; 78.6 ± 15.1 kg) attended three randomized order-balanced, nonblinded sessions, ingesting a single dose of either 0.1, 0.2 or 0.3 g·kg-1BM of NaHCO3 (Intralabs, UK). Fingertip capillary blood was obtained at baseline and every 10 min for 1 hr, then every 15 min for a further 2 hr. There was a significant main effect of both time and condition for all assessed blood analytes (p ≤ .001). Blood analyte responses were significantly lower following 0.1 g·kg-1BM compared with 0.2 g·kg-1BM; bicarbonate concentrations and base excess were highest following ingestion of 0.3 g·kg-1BM (p ≤ .01). Bicarbonate concentrations and pH significantly increased from baseline following all doses; the higher the dose the greater the increase. Large interindividual variability was shown in the magnitude of the increase in bicarbonate concentrations following each dose (+2.0-5; +5.1-8.1; and +6.0-12.3 mmol·L-1 for 0.1, 0.2 and 0.3 g·kg-1BM) and in the range of time to peak concentrations (30-150; 40-165; and 75-180 min for 0.1, 0.2 and 0.3 g·kg-1BM). The variability in bicarbonate responses was not affected by normalization to body mass. These results challenge current practices relating to NaHCO3 supplementation and clearly show the need for athletes to individualize their ingestion protocol and trial varying dosages before competition.en
dc.language.isoenen
dc.publisherHuman Kinetics Journalen
dc.relation.urlhttps://www.ncbi.nlm.nih.gov/pubmed/27098290en
dc.relation.urlhttp://journals.humankinetics.com/doi/abs/10.1123/ijsnem.2015-0286en
dc.rightsBlue - can archive post-print (ie final draft post-refereeing) or publisher's version/PDF-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectextracellular bufferingen
dc.subjectfatigueen
dc.subjectpHen
dc.titleThe dose-response to sodium bicarbonate ingestion highlights the need for individuality in supplementationen
dc.typeArticleen
dc.identifier.eissn1543-2742-
dc.contributor.departmentNottingham Trent Universityen
dc.contributor.departmentCanadian Sport Instituteen
dc.contributor.departmentUniversity of São Pauloen
dc.identifier.journalInternational Journal of Sport Nutrition and Exercise Metabolismen
dc.date.updated2017-09-21T11:58:26Z-
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